Results 171 to 180 of about 407,505 (399)

From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies

Molecular Biotechnology
In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards understanding underlying disease mechanisms, placing a strong emphasis on molecular perturbations and target identification.
Arnab Mukherjee, Suzanna Abraham, Akshita Singh, S. Balaji, K. Mukunthan   +4 more
semanticscholar   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Optimising RNA extraction for paddy bulk soil samples for metatranscriptome sequencing

BMC Research Notes
Objective Extraction of high-quality RNA is crucial for understanding the molecular dynamics of microbiomes in the growth and development of paddy plants.
Sumitra Sivaprakasam, Tan Yee Fan, Yukgehnaish Kumarasan, Erneeza Mohd Hata, Ganesan Vadamalai, Bent Petersen, Thomas Sicheritz-Pontén, Sivachandran Parimannan, Heera Rajandas   +8 more
doaj   +1 more source

Evaluation of the protective efficacy of Ornithodoros moubata midgut membrane antigens selected using omics and in silico prediction algorithms

, 2018
Prosper Obolo-Mvoulouga, Ana Oleaga, Raúl Manzano-Román, Ricardo Pérez–Sánchez   +3 more
openalex   +2 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

HPV specificity and multiple infections and association with cervical cytology in Chongqing, China: a cross-sectional study

BMC Infectious Diseases
Background It is important to assess the relationship between specific HPV genotype or multiple infection and cervical cytology. The protection provided by the HPV vaccine is type-specific, and the epidemiology feature of coinfections needs to be ...
Qinli Luo, Haiyan Zhang, Xianghua Zeng, Na Han, Zhen Ma, Hanyi Luo   +5 more
doaj   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Multi-omics analysis reveals the dominant intestinal microbial strains and metabolites related to the reproductive performance in pregnant sows [PDF]

Qianhong Ye, Tingting Luo, Longshan Han, Yuwen Chen, Y. Hu, Haoyi Jiang, Xiaojian Xu, Xianghua Yan   +7 more
openalex   +1 more source

From Omics to Multi-Omics: Now What?

Bioinformatics is a rapidly evolving field charged with cataloguing, disseminating, and analyzing biological data. Bioinformatics started with genomics, and the distinction remains a source of confusion, but while genomics focuses more narrowly on the genes comprising a genome, bioinformatics now encompasses a much broader range of omics technologies ...
Clair Nelson Hayes, Hikaru Nakahara, Atsushi Ono, Masataka Tsuge, Shiro Oka   +4 more
openaire   +1 more source

Ratoon Season Rice Reduces Methane Emissions by Limiting Acetic Acid Transport to the Rhizosphere and Inhibiting Methanogens

Advanced Science, EarlyView.
This study finds that the interaction between ABA‐OsCIPK2‐OsSWEET1A reduces the allocation of methane producing bacteria carbon source (acetic acid) content to the rhizosphere soil of ratoon season rice, thereby reducing methane emissions. Abstract Rice paddies are a major, persistent source of atmospheric methane (CH4), emission rates depend on the ...
Jingnan Zou, Hailong Xu, Bin Qin, Chaojie Lan, Jinying Li, Bianhong Zhang, Huabin Zhang, Chunlin Guo, Hongfei Chen, Zhongming Fang, Quanzhi Zhao, Wenfei Wang, Changxun Fang, Zhixing Zhang, Wenxiong Lin   +14 more
wiley   +1 more source