Results 181 to 190 of about 407,505 (399)

A novel multi-omics approach for identifying key genes in intervertebral disc degeneration [PDF]

Xuan Zhao, Qijun Wang, Shuaikang Wang, Wei Wang, Xiaolong Chen, Shibao Lu   +5 more
openalex   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Development of a time-resolved fluorescence-based lateral flow immunoassay for rapid and sensitive diagnosis of Middle East respiratory syndrome

Scientific Reports
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-coronavirus (MERS-CoV). Due to its high mortality and lack of a vaccine or treatment, MERS has remained on the WHO’s priority list of diseases with the highest ...
Mi Jeong Kim, Hye-Yeon Kim, Minhye Kim, Eun-Young Shin, Wooyoung Kim, Hyunghoon Kim, Keun Bon Ku, Jong-Hwan Lee, Seung Il Kim, Edmond Changkyun Park   +9 more
doaj   +1 more source

Bioinformatics Prediction for Network-Based Integrative Multi-Omics Expression Data Analysis in Hirschsprung Disease [PDF]

Helena Lucena-Padros, Nereida Bravo‐Gil, Cristina Tous, Elena Rojano, Pedro Seoane, Raquel M. Fernández, Juan A. G. Ranea, Guillermo Antiñolo, Salud Borrego   +8 more
openalex   +1 more source

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes

Advanced Science, EarlyView.
Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji, Xu Liu, Shuai Zhao, Sihan Zhou, Yufan Yang, Ping Zhang, Yu Shi, Wei Qin, Guibing Zhu, Yongguan Zhu, Yanzheng Gao, Jiandong Jiang, Baozhan Wang   +12 more
wiley   +1 more source

A deep learning and molecular modeling approach to repurposing Cangrelor as a potential inhibitor of Nipah virus

Scientific Reports
Deforestation, urbanization, and climate change have significantly increased the risk of zoonotic diseases. Nipah virus (NiV) of Paramyxoviridae family and Henipavirus genus is transmitted by Pteropus bats.
Levin John, Leona Dcunha, Mukhtar Ahmed, Sonet Daniel Thomas, Rajesh Raju, Abhithaj Jayanandan   +5 more
doaj   +1 more source

Microbial-mediated Pesticide Bioremediation: An Approach Through the OMIC Technologies [PDF]

Alexis Rodríguez, María Luisa Castrejón-Godínez, Patricia Mussali-Galante, Efraín Tovar‐Sánchez, José Antonio Díaz-Soto   +4 more
openalex   +1 more source

Multi-omics microsampling for the profiling of lifestyle-associated changes in health [PDF]

, 2023
Xiaotao Shen, Ryan Kellogg, Daniel J. Panyard, Nasim Bararpour, Kevin Erazo Castillo, Brittany Lee‐McMullen, Alireza Delfarah, Jessalyn M. Ubellacker, Sara Ahadi, Yael Rosenberg‐Hasson, Ariel B. Ganz, Kévin Contrepois, Basil Michael, Ian Simms, Chuchu Wang, Daniel Hornburg, M Snyder   +16 more
openalex   +1 more source