Results 211 to 220 of about 407,505 (399)

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

P581: Comparison of GLA variant profile in newborn screening confirmatory testing and diagnostic testing for Fabry disease*

Genetics in Medicine Open
Xiangwen Chen-Deutsch, Rizwan Yousaf, Yinghong Pan, Christin Collins, Madhuri Hegde   +4 more
doaj   +1 more source

Aligned cross-modal integration and regulatory heterogeneity characterization of single-cell multiomic data with deep contrastive learning. [PDF]

Genome Med
Cheng Y, Su Y, Fan Y, Yang Y, Chen X, Wang F, Wong KC, Li X.   +7 more
europepmc   +1 more source

Additional file 7: of An integrated meta-omics approach reveals substrates involved in synergistic interactions in a bisphenol A (BPA)-degrading microbial community

, 2019
Ke Yu, Shan Yi, Bing Li, Feng Guo, Xingxing Peng, Zhiping Wang, Yang Wu, Lisa Alvarez‐Cohen, Tong Zhang   +8 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

P696: Case presentation: Co-segregation of a rare GLA variant of uncertain significance within 2 multiplex families facilitates variant reclassification to pathogenic

Genetics in Medicine Open
Mary Colasanto, Yinghong Pan, Ruby Liu, Christin Collins, Madhuri Hegde   +4 more
doaj   +1 more source

Clustering single-cell multi-omics data via multi-subspace contrastive learning with structural smoothness. [PDF]

Brief Bioinform
Ding Y, Jiang Y, Wang J, Tan D, Su Y, Zheng C.   +5 more
europepmc   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

P651: Genomic breakpoint analysis facilitates the identification of X-chromosomal inversion among molecularly unsolved cases of Duchenne muscular dystrophy

Genetics in Medicine Open
Naga Guruju, Vanessa Jump, Babi Ramesh Reddy Nallamilli, Ruby Liu, Sritha Moram, Christin Collins, Lora Bean, Madhuri Hegde   +7 more
doaj   +1 more source

Unlocking the power of extracellular vesicles: multi-omics integration for cancer biomarker discovery. [PDF]

Biomark Res
Ansermino C, Pavlovic R, Braccia C, Drago D, Anelli C, Andolfo A.   +5 more
europepmc   +1 more source