Results 261 to 270 of about 407,505 (399)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Omics approaches to understand cardiovascular disease. [PDF]

BMC Cardiovasc Disord
Ahmed Z, Jun G.
europepmc   +1 more source

Lipid remodeling During Post-harvest storage of seedless oil palm Fruits: Insights from multi-omics analysis

Xiaoyu Liu, Jerome Jeyakumar John Martin, Xinyu Li, Qihong Li, Lixia Zhou, Rui Li, Dengqiang Fu, Hongxing Cao   +7 more
openalex   +1 more source

Multi-Omics Analysis Reveals the Mechanism of Exosome-Related Genes in Adrenocortical Carcinogenesis [PDF]

Zhiping Chen, Tengfei Liu, Weimin Chen, Guoyang Zhao   +3 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Metabolic reprogramming in the post-metastatic tumor microenvironment: multi-omics insights into determinants of immunotherapy response. [PDF]

Front Immunol
Li M, Wang T, Zhang Z, Dongye Y.
europepmc   +1 more source

Multi-omics analysis of lipids and aroma compounds in beef under grain-fed and grass-fed production methods

Pingyang Li, Yulong Yin, Shijie Fan, Longzhu Zhou, Huihui Tian, Lupei Zhang, Jing Li, Kewei Ma, J. Hu, Yanan Yu, Qingyu Zhao, Youyou Yang, Yahui Wang, Ruiqi Peng, Yan-xiang Zhang, Lu Gao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +18 more
openalex   +1 more source

Single cell and multi omics dissection of periodontal ligament cells identifies regulatory networks and therapeutic targets in skeletal class II malocclusion [PDF]

Yirui Niu, Quan Dai, Min Li
openalex   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Omics in mini-livestock: a genomic perspective on the future of sustainable food systems. [PDF]

Front Genet
Sode A, Halder A, Metzger J.
europepmc   +1 more source