Results 71 to 80 of about 368,665 (261)

Genome sequencing of three bacteria associated to black band disease from a Colombian reef-building coral

Genomics Data, 2017
We announce the draft genome sequence of three Gram-negative bacteria isolated from coral tissues affected with the black band disease (BBD), identified with the NCBI's Assembly Database accession numbers: MBQF, MAYB and MBQE.
Juan Henao, Hermes Pérez, Deisy Abril, Katterine Ospina, Adriana Piza, Kelly Botero, Cristhian Rincón, Jhon Donato, Andrea Hurtado, Erika García, Vanessa Otero, Alexander Del Risco, Brenda Guerra, Yina Cifuentes, Alvaro Ordoñez, Daniel Rojas, Karen Suarez, Daniel Osorio, Andrés Pinzón   +18 more
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Advances in mass spectrometry-based approaches for characterizing monoclonal antibodies: resolving structural complexity and analytical challenges

Journal of Analytical Science and Technology
Mass spectrometry (MS)-based intact mass analysis and structural characterization of biotherapeutic proteins such as monoclonal antibodies (mAbs) are a crucial characterization approach from upstream drug development to downstream product analysis.
Abhik Mojumdar, Hee-Jin Yoo, Duck-Hyun Kim, Jiwon Park, Su-Jin Park, Eunji Jeon, Sunhee Choi, Jung Hoon Choi, Moonhee Park, Geul Bang, Kun Cho   +10 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

AttOmics: attention-based architecture for diagnosis and prognosis from omics data

, 2023
International audienceMotivation The increasing availability of high-throughput omics data allows for considering a new medicine centered on individual patients.
Hanczar, Blaise, Augé, Franck, Milad Rafiee Vahid, Farida Zehraoui, Blaise Hanczar, Rafiee Vahid, Milad, Beaude, Aurélien, Franck Augé, Zehraoui, Farida, Aurélien Beaude   +9 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Arabidopsis thaliana and omics approaches: a review: DOI: 10.5584/jiomics.v5i1.179

, 2021
Arabidopsis thaliana is a small, flowering plant that is widely used as a model organism in plant biology, mainly because it is the first plant to have its entire genome sequenced.
Aurélio Zezzi Arruda, Marco, Miranda Maciel, Bruna Caroline, Toloti Carneiro, Josiane Meire, Chacón Madrid, Katherine   +3 more
core   +1 more source

Phosphoproteome landscape of ARID1A and its implications in DNA damage response and breast cancer pathogenesis

Discover Oncology
ARID1A, a subunit of the SWI/SNF chromatin-remodeling complex, plays a critical role in maintaining genomic stability and regulating estrogen receptor (ER) signaling, yet its phosphorylation dynamics in cancer remain underexplored.
Apoorva Pai Kalasa Anil Kumar, Leona Dcunha, Althaf Mahin, Prathik Basthikoppa Shivamurthy, Suhail Subair, Athira Perunelly Gopalakrishnan, Athira C. Rajeev, Rajesh Raju   +7 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

PROBIC/omics-time-annotation: v1.0.1

A supervised time annotation method for omics experiments using Gaussian ...
Elio Nushi
core   +1 more source