Results 71 to 80 of about 303,207 (215)
Arabidopsis thaliana and omics approaches: a review: DOI: 10.5584/jiomics.v5i1.179
, 2021 Arabidopsis thaliana is a small, flowering plant that is widely used as a model organism in plant biology, mainly because it is the first plant to have its entire genome sequenced.
Aurélio Zezzi Arruda, Marco +3 more
core
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome
Advanced Science, EarlyView.We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu +19 more
wiley +1 more source
Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production
Advanced Science, EarlyView.ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du +4 more
wiley +1 more source
-Omics fields of study related to plant-parasitic nematodes: DOI: 10.5584/jiomics.v3i1.120
, 2013 Plant-parasitic nematodes (PPN) cause significant losses and these pathogens must be addressed amid the growing demand for food, global warming, and the discarded use of inorganic pesticides.
Palomares-Rius, Juan Emilio +1 more
core
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source
Machine learning-driven multi-omics for optimizing biotherapeutic production
Polson, Shawn W.Biotherapeutics, particularly monoclonal antibodies (mAbs) and recombinant adeno-associated viruses (rAAVs), have transformed the treatment landscape for various diseases.
Gurazada, Sai Guna Ranjan
core +1 more source
TOMATOMICS: A Web Database for Integrated Omics Information in Tomato
, 2017 Solanum lycopersicum (tomato) is an important agronomic crop and a major model fruit-producing plant. To facilitate basic and applied research, comprehensive experimental resources and omics information on tomato are available following their development.
Saito, Misa +11 more
core +1 more source
Advanced Science, EarlyView.Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu +18 more
wiley +1 more source
Application of Omics and Systems Medicine in Bladder Cancer
, 2017 Bladder cancer (BC) is the ninth most common cancer in the world. Smoking remains the main disease risk factor which is responsible for about half of the diagnosed BC cases.
Frantzi M. +3 more
core +1 more source