Results 51 to 60 of about 368,665 (261)

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Nanopore-based massively parallel sensing for peptide profiling and protein identification

Nature Communications
Nanopore-based single-molecule sensing holds immense promise for revolutionizing proteomics, however, its practical application remains constrained by low throughput, suboptimal library preparation, and limited analytical power for complex, stochastic ...
Ji Wang, Junyi Chen, Hailin Pan, Fengqin Luo, Wenbing Qin, Huixian Zeng, Xilong Yuan, Yuchen Qiao, Yunfeng Zhang, Yishuo Zhang, Dapeng Wang, Liang Shen, Zhiwei Zhai, Qianhua Zhu, Yuqing Deng, Xiaojing Sheng, Qingqing Xie, Yuning Zhang, Xu Yan, Tao Zeng, Mengzhe Shen, Yinqi Bai, Bo Teng, Yuxiang LI, Chuanyu Liu, Ou Wang, Yuliang Dong, Siqi Liu, Xun Xu   +28 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine

Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy ...
Delrue, Charlotte, Marijn M. Speeckaert, Charlotte Delrue, Speeckaert, Marijn   +3 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

BPDanek/multi-omics-pdd-FL-study: Public Release

, 2023
Federated Learning for multi-omics: a performance evaluation in Parkinson's disease by Benjamin Danek, Mary B.
Lee, Paul Suhwan, Nalls, Mike, Dadu, Anant, Vitale, Dan, Makarious, Mary, Sun, Jimeng, Paul Suhwan, Lee, Faghri, Faraz, Danek, Benjamin   +8 more
core   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Communications Medicine
Background Age and sex significantly impact DNA methylation patterns, however, existing datasets typically include only a subset of methylation sites in the human genome, hindering our thorough understanding.
Wei Chen, Jinjin Xu, Guodan Zeng, Rijing Ou, Changlin Yang, Chuang Xu, Yeqin Wang, Xinxin Wang, Qiuyan Li, Chenhui Zhao, Wenwen Zhou, Yu Lin, Wending Pang, Haiqiang Zhang, Jianhua Yin, Yan Zhang, Xin Jin   +16 more
doaj   +1 more source

An Efficient Nitroblue Tetrazolium Staining and Bright-Field Microscopy Based Method for Detecting and Quantifying Intracellular Reactive Oxygen Species in Oocytes, Cumulus Cells and Embryos

Frontiers in Cell and Developmental Biology, 2020
Assessment of intracellular reactive oxygen species (ROS) is important for evaluating the developmental ability of cumulus-oocyte complexes (COC) and embryos.
Pradeep K. Javvaji, Pradeep K. Javvaji, Arindam Dhali, Joseph R. Francis, Joseph R. Francis, Atul P. Kolte, Anjumoni Mech, Sudhir C. Roy, Ashish Mishra, Raghavendra Bhatta   +9 more
doaj   +1 more source

Assessment of Berberine as a Multi-target Antimicrobial: A Multi-omics Study for Drug Discovery and Repositioning

, 2014
Postgenomics drug development is undergoing major transformation in the age of multi-omics studies and drug repositioning. Rather than applications solely in personalized medicine, omics science thus additionally offers a better understanding of a ...
SAYAR, NİHAT ALPAGU, SARIYAR AKBULUT, BERNA   +1 more
core   +1 more source