Results 51 to 60 of about 303,207 (215)

AttOmics: attention-based architecture for diagnosis and prognosis from omics data

, 2023
International audienceMotivation The increasing availability of high-throughput omics data allows for considering a new medicine centered on individual patients.
Hanczar, Blaise, Augé, Franck, Milad Rafiee Vahid, Farida Zehraoui, Blaise Hanczar, Rafiee Vahid, Milad, Beaude, Aurélien, Franck Augé, Zehraoui, Farida, Aurélien Beaude   +9 more
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Ferric citrate fermentation by a Klebsiella oxytoca strain isolated from pyrite mine drainage producing a relevant exopolysaccharide and its potential applications

, 2013
A Klebsiella oxytoca strain BAS-10 was isolated from pyrite mine drainages. This enterobacter ferments Fe(III)-citrate and Na(I)-citrate. Physiological studies on a relative species K.
BALDI F., BALDI, Franco
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Single-cell omics in personalized medicine

, 2019
Personalized medicine represents one of the major clinical outcomes of omics applications. Genomics and post-DNA omics allow an unprecedented characterization of the molecular landscape of each individual, endowing modern medicine with new predictive ...
Daniela Gabbia, Fortinguerra S., Carrara M., Sorrenti V., Buriani A., Gabbia D., Vincenzo Sorrenti, Stefano Fortinguerra, Maria Carrara, Alessandro Buriani   +9 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

PROBIC/omics-time-annotation: v1.0.1

A supervised time annotation method for omics experiments using Gaussian ...
Elio Nushi
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Risk assessment and communication tools for genotype associations with multifactorial phenotypes: The concept of "edge effect" and cultivating an ethical bridge between omics innovations and society

, 2009
Applications of omics technologies in the postgenomics era swiftly expanded from rare monogenic disorders to multifactorial common complex diseases, pharmacogenomics, and personalized medicine.
Ozdemir, V., Kayaalp, S. O?uz, Somogyi, A., Somogyi, Andrew A., Kolker, Eugene, Suarez-Kurtz, G., Kayaalp, S., Kolker, E., Someya, Toshiyuki, Suarez-Kurtz, Guilherme, Stenne, Raphaelle, Someya, T., Kayaalp, S. Oguz, Somogyi, Andrew A, Stenne, R., Ozdemir, Vural   +15 more
core   +1 more source