Results 41 to 50 of about 368,665 (261)

An overview of single-cell omics, spatial omics, and omics integration in axon regeneration

Toward a systems approach for studying axon regeneration, the extractive omics must be integrated with single cell and spatial omics. Although a comprehensive analytical framework exists for single-cell transcriptomics, single-cell proteomics, lipidomics,
Coronado, Michael, Singal, Avani, Bhattacharya, Sanjoy K., Neag, Emily, Bhattacharya, Nivedita, Almobayed, Amr, Gandikota, Nikhil, Akurati, Sneha, Kishor, Krishna S.   +8 more
core   +1 more source

The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver

, 2021
Type 2 diabetes (T2D) is characterized by pathophysiological alterations in lipid metabolism. One strategy to understand the molecular mechanisms behind these abnormalities is to identify cis-regulatory elements (CREs) located in chromatin-accessible ...
Xing, Pengwei, Wadelius, Claes,, Chen, Xingqi, Diamanti, Klev,, Pan, Gang,, Dang, Yonglong,, Dang, Yonglong, Xing, Pengwei,, Cavalli, Marco,, Pan, Gang, Wadelius, Claes, Diamanti, Klev, Cavalli, Marco, Chen, Xingqi,   +13 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Selphi, a tool for improving genotype imputation accuracy

Scientific Reports
Genotype imputation is a powerful tool for inferring missing genotype data in large-scale genetic studies. Over the last two decades, multiple imputation algorithms have been developed, steadily improving in speed and overall accuracy.
Adriano De Marino, Abdallah Amr Mahmoud, Sandra Bohn, Jon Lerga-Jaso, Biljana Novković, Charlie Manson, Salvatore Loguercio, Andrew Terpolovsky, Mykyta Matushyn, Ali Torkamani, Puya G. Yazdi   +10 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Comparative integrated omics approach sterically understanding hepatic metabolic dynamics in mouse model: DOI: 10.5584/jiomics.v7i1.200

, 2016
Currently, the general approach of analysis is using a single omics technique, however the combined analysis of data by employing multiple omics analyses can enable a more fundamental understanding of the biological phenomena.
Takahashi, Shoko, Jia, Huijuan, Saito, Kenji, Kato, Hisanori   +3 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Epidemiologic characteristics of high-risk HPV and the correlation between multiple infections and cervical lesions

BMC Infectious Diseases, 2023
Background The aim of this study was to determine the prevalence of high-risk human papillomavirus (HR-HPV) and the correlation between multiple infections and cervical lesions.
Qinli Luo, Xianghua Zeng, Hanyi Luo, Ling Pan, Ying Huang, Haiyan Zhang, Na Han   +6 more
doaj   +1 more source

An Innovative Multi-Omics Model Integrating Latent Alignment and Attention Mechanism for Drug Response Prediction

By using omics, we can now examine all components of biological systems simultaneously. Deep learning-based drug prediction methods have shown promise by integrating cancer-related multi-omics data.
Jung-Hsien Chiang, Hui-O Chen, Peng-Chan Lin, Yuan-Chi Cui   +3 more
core   +1 more source