Results 21 to 30 of about 368,665 (261)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mapping mammalian cell-type-specific transcriptional regulatory networks using KD-CAGE and ChIP-seq data in the TC-YIK cell line.

Frontiers in Genetics, 2015
Mammals are composed of hundreds of different cell types with specialized functions. Each of these cellular phenotypes are controlled by different combinations of transcription factors.
Marina eLizio, Marina eLizio, Yuri eIshizu, Yuri eIshizu, Masayoshi eItoh, Masayoshi eItoh, Masayoshi eItoh, Timo eLassmann, Timo eLassmann, Akira eHasegawa, Akira eHasegawa, Atsutaka eKubosaki, Jessica eSeverin, Jessica eSeverin, Hideya eKawaji, Hideya eKawaji, Hideya eKawaji, Yukio eNakamura, Harukazu eSuzuki, Harukazu eSuzuki, Yoshihide eHayashizaki, Yoshihide eHayashizaki, Piero eCarninci, Piero eCarninci, Alistair R R Forrest, Alistair R R Forrest, Alistair R R Forrest   +26 more
doaj   +1 more source

Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas

Nature Communications, 2023
Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring.
Grayson A. Herrgott, James M. Snyder, Ruicong She, Tathiane M. Malta, Thais S. Sabedot, Ian Y. Lee, Jacob Pawloski, Guilherme G. Podolsky-Gondim, Karam P. Asmaro, Jiaqi Zhang, Cara E. Cannella, Kevin Nelson, Bartow Thomas, Ana C. deCarvalho, Laura A. Hasselbach, Kelly M. Tundo, Rehnuma Newaz, Andrea Transou, Natalia Morosini, Victor Francisco, Laila M. Poisson, Dhananjay Chitale, Abir Mukherjee, Maritza S. Mosella, Adam M. Robin, Tobias Walbert, Mark Rosenblum, Tom Mikkelsen, Steven Kalkanis, Daniela P. C. Tirapelli, Daniel J. Weisenberger, Carlos G. Carlotti, Jack Rock, Ana Valeria Castro, Houtan Noushmehr   +34 more
doaj   +1 more source

Improving the completeness of public metadata accompanying omics studies

, 2021
Over the last decade there has been tremendous progress to improve the sharing of genomics data, which allows researchers to easily access the various types of data across a wide range of phenotypes.
MANGUL, SERGHEI, Michael I Love, Annie Wong-Beringer, Anushka Rajesh, Malak S Abedalthagafi, Yutong Chang   +5 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The complete chloroplast genome of Sonneratia griffithii Kurz (Lythraceae)

Mitochondrial DNA. Part B. Resources, 2022
Sonneratia griffithii Kurz is a critically endangered mangrove species that can be found along the western coast of Thailand. In this study, we reported the complete chloroplast genome of S. griffithii. The chloroplast genome is 152,730 bp, consisting of
Duangjai Sangsrakru, Chutima Sonthirod, Wanapinun Nawae, Chutintorn Yundaeng, Waratthaya Promchoo, Wirulda Pootakham, Sithichoke Tangphatsornruang   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The complete mitochondrial genome sequence of the mountain crab Indochinamon bhumibol

Mitochondrial DNA. Part B. Resources, 2021
Indochinamon bhumibol has been found as the biggest freshwater crab in Thailand. In this study, we report the first complete sequence of mitochondrial genome from I. bhumibol encoding 13 protein-coding genes, 22 transfer RNAs, and 2 ribosomal RNAs.
Chaiwat Naktang, Chutima Sonthirod, Duangjai Sangsrakru, Sonicha U-thoomporn, Thavarit Koipokaisawan, Paiboon Panase, Methawat Tuntaisong, Wirulda Pootakham, Sithichoke Tangphatsornruang   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An Omics View of Emery–Dreifuss Muscular Dystrophy

, 2020
International audienceRecent progress in Omics technologies has started to empower personalized healthcare development at a thorough biomolecular level. Omics have subsidized medical breakthroughs that have started to enter clinical proceedings.
Muchir, Antoine, Vignier, Nicolas, Antoine Muchir, Nicolas Vignier   +3 more
core   +1 more source