Results 21 to 30 of about 303,207 (215)

An Omics View of Emery–Dreifuss Muscular Dystrophy

, 2020
International audienceRecent progress in Omics technologies has started to empower personalized healthcare development at a thorough biomolecular level. Omics have subsidized medical breakthroughs that have started to enter clinical proceedings.
Muchir, Antoine, Vignier, Nicolas, Antoine Muchir, Nicolas Vignier   +3 more
core   +1 more source

Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes

, 2022
The European research community, via European Space Agency (ESA) spaceflight opportunities, has significantly contributed toward our current understanding of spaceflight biology.
da Siveira, Willian A., Space Omics Topical Team, Herranz, Raul, Deane, Colleen S.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Integrated Omics Analysis of Sjogren’s Syndrome: DOI: 10.5584/jiomics.v2i2.97

, 2021
Sjögren's syndrome (SS) is a chronic autoimmune disorder clinically characterized by dry mouth and eyes. The pathogenic mechanism of SS is inadequately understood and a long delay from the start of the symptoms to final diagnosis has been frequently ...
Ai, Jiye, Hu, Shen, Misuno, Kaori, Feng, Sizhe   +3 more
core  

The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver

, 2021
Type 2 diabetes (T2D) is characterized by pathophysiological alterations in lipid metabolism. One strategy to understand the molecular mechanisms behind these abnormalities is to identify cis-regulatory elements (CREs) located in chromatin-accessible ...
Xing, Pengwei, Wadelius, Claes,, Chen, Xingqi, Diamanti, Klev,, Pan, Gang,, Dang, Yonglong,, Dang, Yonglong, Xing, Pengwei,, Cavalli, Marco,, Pan, Gang, Wadelius, Claes, Diamanti, Klev, Cavalli, Marco, Chen, Xingqi,   +13 more
core   +1 more source

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. [PDF]

, 2023
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment.
Giordano, Giuseppe N, McEvoy, Donna, Niu, L., Hong, M., Benros, M., Pavo, Imre, Schwenk, J., McCarthy, Mark I, Pearson, Ewan, Johansen, J., IMI DIRECT Consortium, Tajes, Juan Fernandez, Jacobsen, U., Brorsson, Caroline, Brasas, Valentas, Pedersen, A., Bell, Jimmy, Brunak, S., Gudmundsdottir, Valborg, Kennedy, G., Sharma, Sapna, Vogt, Josef, Thomas, E.L., Mazzoni, Gianluca, Mari, Andrea, Hansen, T., Dermitzakis, Emmanouil, Pedersen, O., Haid, M., Lundgaard, A., Biel, J., Forgie, Ian, Webel, Henry, Jones, Angus, Walker, Mark, Blom, Marieke T, Aguayo-Orozco, Alejandro, Mourby, Miranda, Kaye, J., Muilwijk, Mirthe, Pedersen, Helle Krogh, Koivula, R., Vinuela, A., Adamski, Jerzy, Allesøe, Rosa Lundbye, Nissen, Jakob Nybo, Heggie, Alison, Ridderstråle, M., Frost, G., Franks, Paul W, 't Hart, Leen M, Thomsen, Henrik, Ruetten, Hartmut, Banasik, Karina, Raverdy, Violeta, De Masi, Federico, Kokkola, Tarja, Hattersley, A., Vestergaard, Henrik, Hernández Medina, R., Pattou, Francois, Brage, Soren, Mahajan, Anubha, Musholt, Petra B, Rasmussen, S., Chmura, Piotr Jaroslaw, Hansen, Elizaveta, McDonald, Timothy   +67 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Environmental OMICS: Current Status and Future Directions

, 2013
Applications of OMICS to high throughput studies of changes of genes, RNAs, proteins, metabolites, and their associated functionsin cells or organisms exposed to environmental chemicals has led to the emergence of a very active research field ...
Liu, Jianjun,, Peng, Xianxuan, Wentao, Hu, Liu, Jianjun, Foth, Heidi,, Wang, Da-Zhi,, Wang, Da-Zhi, Shi, Leming, Wentao, Hu,, Mei, Nan, Gong, Zhiyuan, Sheehan, David,, Sheehan, David, Ge, Yue, Lam, Siew Hong, Lam, Siew Hong,, Silvestre, Frédéric, Shi, Leming,, Ge, Yue,, Iwahashi, Hitoshi, Mei, Nan,, Cristobal, Susana, Li, Hui,, Silvestre, Frédéric,, Wang, Da Zhi, Teichman, Kevin,, Li, Hui, Gong, Zhiyuan,, Foth, Heidi, Bruno, Maribel,, Chiu, Jen Fu, Chiu, Jen-Fu,, Teichman, Kevin, Iwahashi, Hitoshi,, Peng, Xianxuan,, Chiu, Jen-Fu, Bruno, Maribel, Cristobal, Susana,   +37 more
core   +1 more source