Results 151 to 160 of about 254,235 (292)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Correction: Development of a diagnostic model for ovarian cancer based on machine learning algorithms and functional analysis of key biomarker SOX17. [PDF]

J Ovarian Res
Geng X, Yin M, Zhao H, Zhang Z, Liu S, Liu Y, Zhang S, Liang Y, Song L, Zheng G.   +9 more
europepmc   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Binarization Parameters Affect Quantitative Choriocapillaris Biomarkers Derived from Optical Coherence Tomography Angiography. [PDF]

Biomedicines
Khalatyan AS, Yusef Y, Avetisov KS, Smolin SA, Siplivy VI, Aslamazova AE, Reznikova LV, Machekhina LV, Melnitskaia AA, Strazhesko ID.   +9 more
europepmc   +1 more source

Omnibus Identification Tags

Scrapbook page 1. [Item 1] Packard's Omnibus College member placard compiled by Merle during the Eastern Expedition of her Omnibus College trip [Item 2] Tag (perhaps a bookmark or luggage tag) with Merle's name and hometown compiled by Packard during the

core  

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Reattach-Informed Integrated Occupational Therapy In Persistent Post-Concussion Syndrome: A Pilot Case Series. [PDF]

Clin Neuropsychiatry
Reitsma S, Mehrad A.
europepmc   +1 more source

undangan/poster webinar omnibus law

undangan/poster webinar omnibus ...
Hidayat, Rian
core  

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Findings from Two Online Experiments to Advance the Science on Sexual Orientation and Gender Identity Measurement: An Application to Estimating Cigarette Relighting Behaviors. [PDF]

Psychol Sex Orientat Gend Divers
Ganz O, Gonsalves NJ, Tomaino M, Heckman CJ, Steinberg MB, Manderski MTB.   +5 more
europepmc   +1 more source