Results 21 to 30 of about 148 (67)

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Growth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age‐related reductions. This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay ...
Pere Barceló, Cristina Nicolau, Antoni Gamundí, Maria A. Fiol, Jesús A. F. Tresguerres, Mourad Akaârir, Rubén V. Rial, Giuseppe Cirillo   +7 more
wiley   +1 more source

Biosimilars in Developed and Developing East and Southeast Asian Countries: Japan, South Korea, and Malaysia—Overview, Evolution, and Regulations Assessment

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
The development of biological products has experienced continuous growth over the past three decades. The expiration of patent protection for many biological medicines has led to the development of biosimilars in many countries around the world. This paper reviews the literature on biosimilar drugs and covers their therapeutic status, clinical trials ...
Tomas Gabriel Bas, Carolina Oliu Castillo, Sanjay Garg   +2 more
wiley   +1 more source

Host Cell Protein Clinical Safety Risk Assessment—An Updated Industry Review

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3229-3248, November 2025.
ABSTRACT Host cell proteins (HCP) are process‐related impurities that can co‐purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a well‐controlled manufacturing process and to ...
Lisette Coye, Marisa A. Jones, Georgeen Gaza‐Bulseco, Carmelata Chitikila, Severine Clavier, Delphine Fougeron, Christine Grimaldi, Karen Hurkmans, Richard Hutchinson, Brenda Kellogg, Xinrong Liu, Nisha Palackal, Mahima Tank, Pascal Valax, Thomas Waerner, Fengqiang Wang, Ying Zhang, Yiwei Zhao, Sapphire Sloan, Christina Zuch de Zafra   +19 more
wiley   +1 more source

Jacobsen Syndrome: A Case Report With Olfactory Bulb Agenesis, Severe Endocrinopathy, and Neurodevelopmental Delay

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Jacobsen syndrome is a rare 11q deletion disorder with multisystem involvement. This case highlights a complex unbalanced 11;15 translocation, olfactory bulb agenesis, extensive white matter abnormalities, and severe endocrinopathies, emphasizing the need for comprehensive genetic and neuroimaging evaluations.
Sajjad Ghanim Al‐Badri, Aditya Duhan, Rania H. Al‐Taie, Muntadher Yousif Hasan Al Gehadi, Ibrahim Khalil   +4 more
wiley   +1 more source

A Phase 2 Study of PEGylated Recombinant Human Growth Hormone for 52 Weeks in Short Children Born Small for Gestational Age in China

Clinical Endocrinology, Volume 102, Issue 2, Page 136-146, February 2025.
ABSTRACT Objective Children born small for gestational age (SGA) are at increased risk of health issues. This study evaluated the efficacy, safety and optimal dose of PEGylated‐recombinant human growth hormone (PEG‐rhGH) in these children. Design In this multicentre, randomised, open‐label, Phase 2 trial conducted at nine clinical sites in China ...
Xiaoping Luo, Ling Hou, Yan Zhong, Sha Zhao, Xiaobo Chen, Qian Dong, Hongwei Du, Honghua Lu, Yu Yang, Xian Wu, Feihong Luo, Ruoqian Chen, Zhuangjian Xu, Yaping Ma, Wenhui Song, Mei Feng, Xuefan Gu, Wenjuan Qiu   +17 more
wiley   +1 more source

What is the prevalence of anabolic‐androgenic steroid use among women? A systematic review

Addiction, Volume 119, Issue 12, Page 2088-2100, December 2024.
Abstract Background and aim Evidence suggests there has been an increase in anabolic‐androgenic steroid (AAS) use among women, driven by the evolving landscape of women's participation in sport. However, the extent of use is unknown. This systematic review aimed to estimate the prevalence of women's AAS use.
Timothy Piatkowski, Bianca Whiteside, Jonathan Robertson, April Henning, Eric H. Y. Lau, Matthew Dunn   +5 more
wiley   +1 more source

Letters to the Editor

, 2014
Canadian Journal of Gastroenterology and Hepatology, Volume 28, Issue 8, Page 452-454, 2014.
Miklos Sebeszta, Alex Kudrin
wiley   +1 more source

Overview of Subsequent Entry Biologics for the Management of Inflammatory Bowel Disease and Canadian Association of Gastroenterology Position Statement on Subsequent Entry Biologics

, 2013
Canadian Journal of Gastroenterology and Hepatology, Volume 27, Issue 10, Page 567-571, 2013.
Shane M Devlin, Brian Bressler, Charles N Bernstein, Richard N Fedorak, Alain Bitton, Harminder Singh, Brian G Feagan   +6 more
wiley   +1 more source

Ten years of biosimilars in Europe: development and evolution of the regulatory pathways

Drug Design, Development and Therapy, 2017
Martin Schiestl,1 Markus Zabransky,2 Fritz Sörgel3,4 1Sandoz GmbH, Kundl, Austria; 2Sandoz Biopharmaceuticals, Hexal AG, Holzkirchen, Germany; 3Institute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg, Germany; 4Institute of ...
Schiestl M, Zabransky M, Sörgel F
doaj  

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data

Drug Design, Development and Therapy, 2017
Juan Pedro López-Siguero,1 Roland Pfäffle,2 Philippe Chanson,3 Mieczyslaw Szalecki,4,5 Nadja Höbel,6 Markus Zabransky6 1Servicio de Endocrinología Pediátrica, Hospital Materno-Infantil, Hospital Regional Universitario de M&
López-Siguero JP, Pfäffle R, Chanson P, Szalecki M, Höbel N, Zabransky M   +5 more
doaj