Results 71 to 80 of about 1,576 (169)

Conceptual Design of a Generic Data Harmonization Process for OMOP CDM

, 2023
To gain insight into the real-life care of patients in the healthcare system, data from hospital information systems and insurance systems are required. Consequently, linking clinical data with claims data is necessary. To ensure their syntactic and semantic interoperability, the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)
Elisa Henke, Michele Zoch, Yuan Peng, Ines Reinecke, Martin Sedlmayr, Franziska Bathelt   +5 more
openaire   +1 more source

Development and validation of a computable phenotype for adolescent idiopathic scoliosis

Learning Health Systems, Volume 9, Issue 4, October 2025.
Abstract Introduction There remains a lack of understanding of the etiology and treatment effectiveness for Adolescent idiopathic scoliosis (AIS). The objective of this study was to develop and validate a computable phenotype for patients with AIS to facilitate rapid learning through large‐scale observational research using real‐world data.
Sarah B. Floyd, Ashley Mills, Jason Woloff, Christian Lowson, Coleman Hilton, Donna Oeffinger, Steven Hwang   +6 more
wiley   +1 more source

Utility of Treatment Pattern Analysis Using a Common Data Model: A Scoping Review [PDF]

Healthcare Informatics Research
Objectives We aimed to derive observational research evidence on treatment patterns through a scoping review of common data model (CDM)-based publications.
Eun-Gee Park, Min Jung Kim, Jinseo Kim, Kichul Shin, Borim Ryu   +4 more
doaj   +1 more source

German Claims Data for Real-World Research: Content Coverage Evaluation in OMOP CDM

, 2023
Research on real-world data is becoming increasingly important. The current restriction to clinical data in Germany limits the view of the patient. To gain comprehensive insights, claims data can be added to the existing knowledge. However, standardized transfer of German claims data into OMOP CDM is currently not possible.
Elisa, Henke, Michéle, Zoch, Ines, Reinecke, Melissa, Spoden, Thomas, Ruhnke, Christian, Günster, Martin, Sedlmayr, Franziska, Bathelt   +7 more
openaire   +2 more sources

Mapping the Bulgarian Diabetes Register to OMOP CDM: Application Results

Background: The Bulgaria Diabetes Register (BDR) contains more than 380 millions of pseudonymized outpatient records with proprietary data structures and format. Objectives: This paper presents the application results and experience acquired during the process of mapping such observational health data to OMOP CDM with the objective of publishing it in ...
Krastev, Evgeniy, Markov, Emanuil, Abanos, Simeon, Krasteva, Ralitsa, Tcharaktchiev, Dimitar   +4 more
openaire   +2 more sources

How to Improve the Reuse of Clinical Data-- openEHR and OMOP CDM

Journal of Physics: Conference Series, 2020
Abstract All medical big data reuse projects are faced with the challenging problem of collecting and transforming heterogeneous data from different sources in a distributed research network. Both openEHR and OMOP CDM are open source tools for medical data.
Bei Li, Rich Tsui
openaire   +1 more source

Recommendations to Enable Broader Use of Real‐World Evidence to Inform Decision‐Making Throughout Pharmacovigilance Signal Management

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 10, October 2025.
ABSTRACT Introduction Despite substantial investments in analytical infrastructure and scientific research related to the development and analysis of real‐world evidence in support of signal management, the impact on routine pharmacovigilance activities has been limited.
G. Niklas Norén, Katherine Donegan, Monica A. Muñoz, Thamir M. Alshammari, Nicole Pratt, Gianmario Candore, Daniel Morales, Peter Rijnbeek, Andrew Bate, Rodrigo Postigo, Sengwee Toh, Gianluca Trifirò, Montse Soriano Gabarro, Alison Cave, Patrick B. Ryan   +14 more
wiley   +1 more source

Integrating Clinical Data and Medical Imaging in Lung Cancer: Feasibility Study Using the Observational Medical Outcomes Partnership Common Data Model Extension

JMIR Medical Informatics
BackgroundDigital transformation, particularly the integration of medical imaging with clinical data, is vital in personalized medicine.
Hyerim Ji, Seok Kim, Leonard Sunwoo, Sowon Jang, Ho-Young Lee, Sooyoung Yoo   +5 more
doaj   +1 more source

Secular Trends in the Use of Valproate‐Containing Medicines in Women of Childbearing Age in Europe: A Multinational DARWIN EU Network Study

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 10, October 2025.
ABSTRACT Background Valproate‐containing medicines (VPA) are first‐line treatments for epilepsy; however, they pose teratogenic risks, restricting their use in women of childbearing age. We aimed to estimate the secular trends in the use of VPA and alternative treatments in young women, and to characterise dose/strength, treatment duration, and ...
Lucía Bellas, Martí Català, Edward Burn, Yuchen Guo, Mike Du, Katia Verhamme, Egil Fridgeirsson, Talita Duarte‐Salles, Tommi Kauko, Eeva Kronqvist, James T. Brash, Sarah Seager, Daniel Prieto‐Alhambra, Annika M. Jödicke, Albert Prats‐Uribe   +14 more
wiley   +1 more source

Association of Omeprazole‐Related Myopathy With Drug–Drug and Drug–Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case–Control Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 654-666, October 2025.
ABSTRACT Background Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy.
Eugene Jeong, Aditi Shendre, Yu Su, Xingyi Guo, Lang Li, You Chen   +5 more
wiley   +1 more source