Results 51 to 60 of about 151,648 (281)

USE OF THE OPERATIVE GROUP IN HEALTH CARE: AN INTEGRATIVE REVIEW

open access: yesCogitare Enfermagem, 2014
This study aimed to identify how the Operative Group has been used in the area of health, and what the evidence is for its use in the scientific literature.
Roselma Lucchese   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Acesso a bases de dados em linha e em CD-ROM: algumas considerações sobre a sua implantação em países em desenvolvimento

open access: yesCiência da Informação, 1991
Apresenta-se um estudo comparativo do acesso a bases de dados em linha e em CD-ROM, a fim de auxiliar os profissionais da informação de países em desenvolvimento em seus processos de tomada de decisão para incorporação destas tecnologias aos seus ...
Roseane Regina Velho Lopes
doaj  

Comparison of OMI NO2 tropospheric columns with an ensemble of global and European regional air quality models [PDF]

open access: yesAtmospheric Chemistry and Physics, 2010
We present a comparison of tropospheric NO2 from OMI measurements to the median of an ensemble of Regional Air Quality (RAQ) models, and an intercomparison of the contributing RAQ models and two global models for the period July 2008–June 2009 over ...
D. Zyryanov   +23 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

A Kernel-Driven BRDF Approach to Correct Airborne Hyperspectral Imagery over Forested Areas with Rugged Topography

open access: yesRemote Sensing, 2020
Airborne hyper-spectral imaging has been proven to be an efficient means to provide new insights for the retrieval of biophysical variables. However, quantitative estimates of unbiased information derived from airborne hyperspectral measurements ...
Wen Jia   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

El sistema de ayuda al usuario de un catálogo en línea de acceso público: delimitación teórica y propuesta práctica

open access: yesDocumentación de las Ciencias de la Información, 2007
In recent years, research on online public access catalogs has been directed at improving two different areas: increasing the potential of information retrieval and also improving the human-system relationship by creating friendlier and more intuitive ...
Purificación Moscoso Castro   +1 more
doaj  

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