Results 61 to 70 of about 178,231 (331)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Software-implemented attack tolerance for critical information retrieval [PDF]

, 2004
The fast-growing reliance of our daily life upon online information services often demands an appropriate level of privacy protection as well as highly available service provision. However, most existing solutions have attempted to address these problems
Yang, Yunwen (Erica)
core  

O poder cognitivo das redes neurais artificiais modelo Art1 na recuperação da informação

Ciência da Informação, 2009
O artigo relata um experimento de simulação computacional de um sistema de recuperação da informação composto por uma base de índices textuais de uma amostra de documentos, um software de rede neural artificial implementando conceitos da Teoria da ...
Ethel Airton Capuano
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Combining relevance information in a synchronous collaborative information retrieval environment [PDF]

, 2008
Traditionally information retrieval (IR) research has focussed on a single user interaction modality, where a user searches to satisfy an information need.
Smeaton, Alan F., Foley, Colum, Jones, Gareth J.F.   +2 more
core  

USE OF THE OPERATIVE GROUP IN HEALTH CARE: AN INTEGRATIVE REVIEW

Cogitare Enfermagem, 2014
This study aimed to identify how the Operative Group has been used in the area of health, and what the evidence is for its use in the scientific literature.
Roselma Lucchese, Ivânia Vera, Patrícia Rosa Benicio, Aline de Fátima da Silva, Denize Bouttelet Munari, Cinira Magali Fortuna   +5 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An affect-based video retrieval system with open vocabulary querying [PDF]

, 2010
Content-based video retrieval systems (CBVR) are creating new search and browse capabilities using metadata describing significant features of the data.
Hau Chan, Ching, Jones, Gareth J.F.
core  

Comparison of OMI NO₂ tropospheric columns with an ensemble of global and European regional air quality models [PDF]

Atmospheric Chemistry and Physics, 2010
We present a comparison of tropospheric NO2 from OMI measurements to the median of an ensemble of Regional Air Quality (RAQ) models, and an intercomparison of the contributing RAQ models and two global models for the period July 2008–June 2009 over ...
D. Zyryanov, J. Vira, A. Strunk, R. Bergstrom, B. Amstrup, E. Friese, I. Kioutsioukis, M. D'Isidoro, L. Robertson, A. Gross, O. Stein, J. Flemming, A. Valdebenito, M. Sofiev, G. Foret, K. F. Boersma, H. Elbern, A. Poupkou, H. J. Eskes, V. Huijnen, A. Maurizi, D. Melas, V.-H. Peuch, C. Zerefos   +23 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source