Results 91 to 100 of about 3,234,483 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring: Novel Application Approaches and Insights

Frontiers in Bioengineering and Biotechnology, 2020
Monitoring and control of fermentation processes remain a crucial challenge for both laboratory and industrial-scale experiments. Reliable identification and quantification of the key process parameters in on-line mode allow operation of the fermentation
Katrin Pontius, Daria Semenova, Yuliya E. Silina, Krist V. Gernaey, Helena Junicke   +4 more
doaj   +1 more source

On-line confidence monitoring during decision making

Cognition, 2018
Humans can readily assess their degree of confidence in their decisions. Two models of confidence computation have been proposed: post-hoc computation using post-decision variables and heuristics, versus online computation using continuous assessment of evidence throughout the decision-making process.
Dotan, Dror, Meyniel, Florent, Dehaene, Stanislas   +2 more
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Результати впровадження системи безперервного контролю характеристик основної ізоляції високовольтних трансформаторів струму на підстанції «Дніпро-Донбас 330»

Elektrotehnìka ta Elektroenergetika, 2011
Устатті описано результати впровадження системи безперервного автоматизованого контролю основної ізоляції трансформаторів струму 330 кВ на основі розроблених алгоритмів вимірювання і моделі прогнозу залишкового ресурсу.
P. D. Andrienko, A. A. Sakhno
doaj   +1 more source

High-dispersion spectroscopic monitoring of the Be/X-ray binary A0535+26/V725 Tau I: The long-term profile variability

, 2010
We report on optical high-dispersion spectroscopic monitoring observations of the Be/X-ray binary A0535+26/V725 Tau, carried out from November 2005 to March 2009.
A. Imada, A. T. Okazaki, Aab, Bagnuolo, Berio, Bjorkman, Caballero, Carciofi, Cassinelli, Clark, Clark, Clark, Coe, Coe, Coe, D. Nogami, E. Kambe, Ekström, Giangrande, Grundstrom, Haigh, Hutchings, Hutchings, J. Tanaka, Larionov, Levine, Marsh, McSwain, Motch, Negueruela, O. Hashimoto, Ogilvie, Okazaki, Okazaki, Okazaki, Oktariani, Papaloizou, Peters, Porter, Reig, Rosenberg, S. Honda, Tueller, Vakili, Wang, Y. Ishino, Y. Moritani, Y. Suzuki, Štefl   +48 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A CUSUM test with sliding reference for ground resonance monitoring [PDF]

, 2011
Ground resonance is potentially destructive oscillations that may develop on helicopters rotors when the aircraft is on or near the ground. Therefore, this unstable phenomenon has to be detected before it occurs in order to be avoided by the pilot.
Jhinaoui, Ahmed, Mevel, Laurent, Morlier, Joseph   +2 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source