Results 71 to 80 of about 2,155,238 (316)

Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction [PDF]

, 2002
Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune((R))) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory.
Fleischer, Claudia, Groetzner, Jan, Spöhrer, Ute, Meiser, Bruno, Seidel, Dietrich, Vogeser, Michael   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Monitoring Key Parameters in Bioprocesses Using Near-Infrared Technology

Sensors, 2014
Near-infrared spectroscopy (NIRS) is known to be a rapid and non-destructive technique for process monitoring. Bioprocesses are usually complex, from both the chemical (ill-defined medium composition) and physical (multiphase matrix) aspects, which ...
Elena Tamburini, Maria Gabriella Marchetti, Paola Pedrini   +2 more
doaj   +1 more source

Application of Superluminescent Light Emitting Diode to Electrooptic Modulator Based PD Continuous On-line Monitoring System

, 2005
Partial discharge monitoring provides effective evaluation of power cables, particularly of joints that are installed on site. Continuous on-line monitoring can provide information about progressing degradation under operational stresses, thus reducing ...
Tian, Y., Sutton, S.J., Lewin, P.L., Swingler, S.G., Wilkinson, J.S.   +4 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ОСОБЛИВОСТІ МОНІТОРИНГУ ТЕХНІЧНОГО СТАНУ ОСНОВНОЇ ІЗОЛЯЦІЇ ВИСОКОВОЛЬТНИХ УВОДІВ І ТРАНСФОРМАТОРІВ СТРУМУ

Elektrotehnìka ta Elektroenergetika, 2014
статті представлено аналіз особливостей моніторингу технічного стану головної ізоляції трансформаторів струму та уводів з точки зору вибору діагностичних параметрів, описано результати вимірювання характеристик часткових розрядів в ізоляції ...
P. D. Andrienko, A. A. Sakhno, S. P. Konogray, A. G. Spitsa, L. S. Skrupskaya   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Cost Effectiveness Analysis of Clinically Driven versus Routine Laboratory Monitoring of Antiretroviral Therapy in Uganda and Zimbabwe [PDF]

, 2012
BACKGROUND: Despite funding constraints for treatment programmes in Africa, the costs and economic consequences of routine laboratory monitoring for efficacy and toxicity of antiretroviral therapy (ART) have rarely been evaluated.
Amurwon, Jovita, Abdel G. Babiker (158530), Darbyshire Janet, Antonieta Medina Lara (168787), Antonieta Medina Lara, Charles F. Gilks (164480), Munderi Paula, Wakaholi, Barbara Nyanzi, Walker, A Sarah, Babiker, AG, Elly Katabira, Paula Munderi, Reid Andrew, Kasirye, Ronnie, James Hakim, Andrew Reid, Gibb, Diana M., Janet Darbyshire (59117), Jesse Kigozi (168794), Katabira Elly, Gilks, CF, Gilks, Charles F, Kityo Cissy, Darbyshire, J, Jovita Amurwon, Cissy Kityo, Walker A. Sarah, Kigozi, Jesse, Mugyenyi Peter, Barbara Nyanzi Wakaholi, Gibb, DM, Mugyenyi, Peter, Lara, AM, Walker, AS, Muchabaiwa Lazarus, Reid, Andrew, Peter Mugyenyi (168847), Darbyshire, Janet, Diana M. Gibb (164420), Medina Lara Antonieta, Ssali Francis, Kityo, Cissy, Grosskurth Heiner, Grosskurth, Heiner, Abdel G Babiker, Ruben E. Mujica Mota (168817), Kasirye Ronnie, Nyanzi Wakaholi, B, Jesse Kigozi, Walker, Ann, Wakaholi, BN, Team, Ssali, Francis, Ssali, F, Lazarus Muchabaiwa, Medina Lara, Antonieta, Hakim James, Walker, A. Sarah, Peter Mugyenyi, Janet Darbyshire, Gilks, Charles F., Team, DARTT, DART Trial Team, Diana M Gibb, Muchabaiwa, L, Elly Katabira (10701), A Sarah Walker, Kasirye, R, Ronnie Kasirye (168825), Paula Munderi (164469), Katabira, Elly, Muchabaiwa, Lazarus, Munderi, P, Hakim, J, Gibb, Diana M, Barbara Nyanzi Wakaholi (168811), Mota, Ruben E. Mujica, Gilks Charles F., Amurwon Jovita, Jovita Amurwon (168800), James Hakim (164478), Babiker, Abdel G, Amurwon, J, Charles F Gilks, Kityo, C, Nyanzi Wakaholi, Barbara, Babiker, Abdel G., Gibb Diana M., Mota, REM, Cissy Kityo (168842), Mujica Mota, Ruben E, Heiner Grosskurth (37057), Ruben E Mujica Mota, Reid, A, Medina-Lara, A, Kigozi Jesse, Francis Ssali, Mujica Mota Ruben E., Andrew Reid (168831), A. Sarah Walker (145609), Heiner Grosskurth, Lara, Antonieta Medina, Katabira, E, Ronnie Kasirye, Munderi, Paula, Grosskurth, H, Hakim, James, Francis Ssali (158549), Mujica-Mota, Ruben, Lazarus Muchabaiwa (168805), Kigozi, J, Mugyenyi, P, Nyanzi Wakaholi Barbara, Babiker Abdel G.   +113 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Automated Electrochemical Glucose Biosensor Platform as an Efficient Tool Toward On-Line Fermentation Monitoring: Novel Application Approaches and Insights

Frontiers in Bioengineering and Biotechnology, 2020
Monitoring and control of fermentation processes remain a crucial challenge for both laboratory and industrial-scale experiments. Reliable identification and quantification of the key process parameters in on-line mode allow operation of the fermentation
Katrin Pontius, Daria Semenova, Yuliya E. Silina, Krist V. Gernaey, Helena Junicke   +4 more
doaj   +1 more source