Results 91 to 100 of about 2,155,238 (316)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Online Prediction of Physico-Chemical Quality Attributes of Beef Using Visible—Near-Infrared Spectroscopy and Chemometrics

open access: yesFoods, 2019
The potential of visible−near-infrared (Vis−NIR) spectroscopy to predict physico-chemical quality traits in 368 samples of bovine musculus longissimus thoracis et lumborum (LTL) was evaluated.
Amna Sahar   +6 more
doaj   +1 more source

Data management of on-line partial discharge monitoring using wireless sensor nodes integrated with a multi-agent system [PDF]

open access: yes, 2007
On-line partial discharge monitoring has been the subject of significant research in previous years but little work has been carried out with regard to the management of on-site data.
Martin David Judd   +8 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Condition Monitoring of Power Cables

open access: yes, 2007
A National Grid funded research project at Southampton has investigated possible methodologies for data acquisition, transmission and processing that will facilitate on-line continuous monitoring of partial discharges in high voltage polymeric cable ...
Swaffield, D J   +3 more
core  

An adaptive control system for off-line programming in robotic gas metal arc welding. [PDF]

open access: yes, 1997
The aim of this work was to develop an integration concept for using off-line programming in robotic gas metal arc welding of thin sheet steel. Off line -welding parameter optimization and on-line monitoring and adaptive control of process stability ...
Carvalho, G. C.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Off-line and on-line optical monitoring of microalgal growth

open access: yesPeerJ, 2019
The growth of Chlamydomonas reinhardtii microalgae cultures was successfully monitored, using classic off-line optical techniques (optical density and fluorescence) and on-line analysis of digital images. In this study, we found that the chlorophyll fluorescence ratio F
Hugo-Enrique Lazcano-Hernández   +4 more
openaire   +3 more sources

Sensor validation of a Structural Health Monitoring Process for Aircraft Nacelle [PDF]

open access: yes, 2014
This paper details the implementation process of an embedded structural health monitoring (SHM) system enabling condition-based maintenance of aircraft nacelles.
GUSKOV, Mikhail   +4 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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