Results 121 to 130 of about 3,234,483 (284)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy. [PDF]
Anal Bioanal Chem, 2023 Müller DH, Börger M, Thien J, Koß HJ.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Potential of Visible Spectroscopy as a Tool for the In-Line Monitoring of Lignin Methylolation. [PDF]
Polymers (Basel), 2022 Gonçalves S +5 more
europepmc +1 more source
Development report: Automatic System Test and Calibration (ASTAC) equipment [PDF]
A microcomputer based automatic test system was developed for the daily performance monitoring of wind energy system time domain (WEST) analyzer. The test system consists of a microprocessor based controller and hybrid interface unit which are used for ...
Thoren, R. J.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
QCL-IR Spectroscopy for In-Line Monitoring of Proteins from Preparative Ion-Exchange Chromatography. [PDF]
Anal Chem, 2022 Akhgar CK +4 more
europepmc +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2017 Objective To evaluate the value of on-line clearance monitoring( OCM) in hemodialysis adequacy evaluation. Methods 135 maintenance hemodialysis patients were investigated by using OCM appliance,including 66 males and 69 females,with the mean SD age of ...
ZHENG Xin +3 more
doaj
Acoustic Focusing of Protein Crystals for In-Line Monitoring and Up-Concentration during Serial Crystallography. [PDF]
Anal Chem, 2022 Hammarström B +5 more
europepmc +1 more source