Results 131 to 140 of about 2,769,403 (287)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Characterization of the resistance mechanism against BYDV-PAV in maize

Frontiers in Agronomy
Arthropods threaten crop production by feeding on plants and, most importantly, by transmitting viruses. BYDV-PAV is the most prevalent virus species that causes barley yellow dwarf disease, one of the most economically important viral diseases affecting
Maria Schmidt, Torsten Will, Britta Ruckwied, Antje Habekuß, Benjamin Stich, Benjamin Stich, Benjamin Stich   +6 more
doaj   +1 more source

Tank tests to determine the effect of varying design parameters of planing-tail hulls II : effect of varying depth of step, angle of after- body keel, length of afterbody chine, and gross load [PDF]

The second part of a series of tests made in Langley tank no. 2 to determine the effect of varying design parameters of planing-tail hulls is presented.
Dawson, John R, Hay, Elizabeth S, Mckann, Robert   +2 more
core   +1 more source

Holding On To History

, 2020
When I searched for the story of Georges Lieber, the very man whose drive to resist inspired the concept for this essay, I could not find it. The only trace of him was his record on the Yad Vashem database which merely states that he was a student and ...
Cromer, Jesse A.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Theorem on resistive networks

Electronics Letters, 1967
A theorem on (m+1) terminal resistive networks is stated. As a consequence, an (m+1)terminal network may be considered an m dimensional, strongly Ptolemaic metric space. Furthermore, the restrictions on the n×n open-circuit-impedance matrix Z of a resistive n port based on m+1 terminals, are at the most quadratic in entries Zpq of Z.
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Factors associated with disease in farmed and wild salmonids caused by Tenacibaculum maritimum: a scoping review

Frontiers in Aquaculture
IntroductionYellow mouth disease, caused by Tenacibaculum maritimum, is an important disease of farmed salmonids. Disease management currently necessitates the use of antimicrobials, raising concerns about antimicrobial resistance (AMR) in aquatic and ...
Rebecca M. Wassmuth, Rebecca M. Wassmuth, Rebecca M. Wassmuth, Etienne J. de Jongh, Etienne J. de Jongh, Etienne J. de Jongh, F. Carl Uhland, Richard J. Reid-Smith, Richard J. Reid-Smith, Richard J. Reid-Smith, Kelsey Robertson, Kelsey Robertson, Simon J. G. Otto, Simon J. G. Otto, Simon J. G. Otto   +14 more
doaj   +1 more source