Results 131 to 140 of about 51,167,879 (314)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of immunogold test strips for chilli veinal mottle virus detection using monoclonal antibodies against the CP

Frontiers in Microbiology
Chilli veinal mottle virus (ChiVMV), a member of the Potyviridae family, a major threat to solanaceous crops, including tobacco and peppers, in China, where it causes systemic necrosis, leaf mottling, and significant yield losses.
Fang Wang, Fang Wang, Chuantao Xu, Ying Chen, Ying Chen, Ke Wang, Xueying An, Xueying An, Benguo Zhou   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

National Surveillance and Reporting of Antimicrobial Resistance and Antibiotic Usage for Human Health in Australia [PDF]

, 2013
Antimicrobial resistance (AMR) is a leading worldwide threat to the wellbeing of patients, and the safety and quality of health care. Although they have been available only for the past 80 years, antibiotics are accepted as an essential part of everyday
Christiansen, Keryn, Standing Committee, Antimicrobial Resistance, Cruickshank, Marilyn, Shaban, Ramon   +3 more
core  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Sepsis Outcome Programme (GNSOP) Annual Report 2017 [PDF]

, 2019
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric Gram-negative pathogens.
Bell, J.M. for the Australian Group on Antimicrobial Resistance, Gottlieb, T., Coombs, G.W. (Eds), Daley, D.A.   +3 more
core  

Characterization of the resistance mechanism against BYDV-PAV in maize

Frontiers in Agronomy
Arthropods threaten crop production by feeding on plants and, most importantly, by transmitting viruses. BYDV-PAV is the most prevalent virus species that causes barley yellow dwarf disease, one of the most economically important viral diseases affecting
Maria Schmidt, Torsten Will, Britta Ruckwied, Antje Habekuß, Benjamin Stich, Benjamin Stich, Benjamin Stich   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect on oxides on surface topography and thermal contact resistance [PDF]

, 1979
The effect of oxides on the topographies of various random engineering surfaces and steady-state thermal contact resistances between oxidefree and oxidized metallic surfaces in contact in high vacua have been investigated. The results of many previous
Mian, M. N.
core