Results 171 to 180 of about 51,151,627 (314)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Author Correction: Semi-automated surveillance of surgical site infections using machine learning and rule-based classification models

npj Digital Medicine
Américo Agostinho, Etienne Chalot, Daniel Teixeira, Davide Bosetti, Niccolò Buetti, Gaud Catho, Stephan Harbarth, Mohamed Abbas   +7 more
doaj   +1 more source

Emergence of Fosfomycin Resistance Among ESBL-Producing <i>Escherichia coli</i> in Abadan, Southwestern Iran. [PDF]

Health Sci Rep
Jomehzadeh N, Fakari A.
europepmc   +1 more source

Resisting resistance [PDF]

Nature Reviews Microbiology, 2012
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru

Journal of Tropical Medicine
Rosario Oporto-Llerena, Rosario Huerto-Huánuco, Yaneth Quispe-Hualpa, Luciano A. Palomino-Kobayashi, Gabriela Soza, Jesús Rojas-Jaimes, Patricia Gonzales, Luis Pollack, Andrea C. Gomez, Gina Salvador-Luján, Edwin Cuaresma, Nestor Luque, Martín Casapia, Kovy Arteaga-Livias, Yolanda Sáenz, Maria J. Pons, Joaquim Ruiz   +16 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Researching Resistance: Methodological challenges, ethical concerns and the future of Resistance Studies

, 2017
Special issue if Journal of Resistance Studies, focusing on methodology and ethics in resistance ...
Törnberg, Anton,
core  

Genomics of Hospital-Associated Brazilian Multidrug-Resistant Klebsiella pneumoniae: Abundance of Resistance and Virulence Genes and Mosaicism of the bla_KPC-2 Genetic Context Among Enterobacterales. [PDF]

Curr Microbiol
Pereira MF, Rossi CC, Borghi M, Januário BD, Andrade-Oliveira AL, Bazzolli DMS, de Almeida LGP, de Vasconcelos ATR, Nicolás MF, Schuenck RP.   +9 more
europepmc   +1 more source