Results 51 to 60 of about 51,151,627 (314)

Acceptability of an alcohol-based handrub gel with superfatting agents among healthcare workers: a randomized crossover controlled study

Antimicrobial Resistance and Infection Control, 2022
Introduction Healthcare workers often experience skin dryness and irritation from performing hand hygiene frequently. Low acceptability and tolerability of a formulation are barriers to hand hygiene compliance, though little research has been conducted ...
Alexandra Peters, Jennifer Carry, Charlotte Cave, Julien Sauser, Didier Pittet   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Semi-automated surveillance of surgical site infections using machine learning and rule-based classification models

npj Digital Medicine
Surgical site infections (SSIs), among the most frequent healthcare-associated infections, require surveillance, but traditional methods are labour-intensive.
Américo Agostinho, Etienne Chalot, Daniel Teixeira, Davide Bosetti, Niccolò Buetti, Gaud Catho, Stephan Harbarth, Mohamed Abbas   +7 more
doaj   +1 more source

Resistance in Vancomycin-Resistant Enterococci

Infectious Disease Clinics of North America, 2020
Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges ...
William R, Miller, Barbara E, Murray, Louis B, Rice, Cesar A, Arias   +3 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Investigation of the impact of the NICE guidelines regarding antibiotic prophylaxis during invasive dental procedures on the incidence of infective endocarditis in England: an electronic health records study

BMC Medicine, 2020
Background Infective endocarditis is an uncommon but serious infection, where evidence for giving antibiotic prophylaxis before invasive dental procedures is inconclusive.
T. Phuong Quan, Berit Muller-Pebody, Nicola Fawcett, Bernadette C. Young, Mehdi Minaji, Jonathan Sandoe, Susan Hopkins, Derrick Crook, Timothy Peto, Alan P. Johnson, A. Sarah Walker   +10 more
doaj   +1 more source

Perspective on Clinically-Relevant Antimicrobial Resistant Enterobacterales in Food: Closing the Gaps Using Genomics

Frontiers in Sustainable Food Systems, 2021
Antimicrobial resistance is one of the most important public health concerns—it causes 700,000 deaths annually according to the World Health Organization (WHO). Enterobacterales such as E.
Constanza Díaz-Gavidia, Constanza Díaz-Gavidia, Francisca P. Álvarez, Francisca P. Álvarez, Jose M. Munita, Jose M. Munita, Sandra Cortés, Sandra Cortés, Andrea I. Moreno-Switt, Andrea I. Moreno-Switt   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fitness costs associated with evolved herbicide resistance alleles in plants [PDF]

, 2009
Predictions based on evolutionary theory suggest that the adaptive value of evolved herbicide resistance alleles may be compromised by the existence of fitness costs.
Martin M. Vila‐Aiub, Powles, Stephen B., Stephen B. Powles, Vila-Aiub, Martin M., Neve, Paul, Paul Neve   +5 more
core   +1 more source