Results 81 to 90 of about 154,218 (242)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Key Technologies and Construction model for Unmanned Smart Farms: Taking the "1.5-Ton Grain per Mu" Unmanned Farm as An Example

智慧农业
[Objective]As a key model of smart agriculture, the unmanned smart farm aims to develop a highly intelligent and automated system for high grain yields.
LIU lining, ZHANG Hongqi, ZHANG Ziwen, ZHANG Zhenghui, WANG Jiayu, LI Xuanxuan, ZHU Ke, LIU Pingzeng   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An innovative mobile application for construction programme managers [PDF]

, 2010
Construction programme management is a complex and information-intensive environment. The construction programme management team requires access to construction information in real-time and when needed. The current increasing use of mobile devices offers
Anumba, Chimay, Carrillo, Patricia, Fathi, Mohamad Syazli   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The building information modeling for the retrofitting of existing buildings. A case study in the University of Cagliari. [PDF]

, 2018
Italy's very consistent buildings stock has become the major field for real estate investments and for the related projects and actions. The urge of working on built environment is however facing some crucial issues.
Chiara Tagliabue, Lavinia, Desogus, Giuseppe, Martino Di Giuda, Giuseppe, Monni, Giuseppina, Quaquero, Emanuela, Sanna, Antonello, Villa, Valentina   +6 more
core   +1 more source

Integrated Dynamic Facade Control with an Agent-based Architecture for Commercial Buildings [PDF]

, 2020
Dynamic façades have significant technical potential to minimize heating, cooling, and lighting energy use and peak electric demand in the perimeter zone of commercial buildings, but the performance of these systems is reliant on being able to balance ...
Blum, David H, Gehbauer, Christoph, Lee, Eleanor S, Wang, Taoning   +3 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Lessons From 3 Longitudinal Sensor-Based Human Behavior Assessment Field Studies and an Approach to Support Stakeholder Management: Content Analysis

Journal of Medical Internet Research
BackgroundPervasive technologies are used to investigate various phenomena outside the laboratory setting, providing valuable insights into real-world human behavior and interaction with the environment.
Johanna Kallio, Atte Kinnula, Satu-Marja Mäkelä, Sari Järvinen, Pauli Räsänen, Simo Hosio, Miguel Bordallo López   +6 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source