Results 71 to 80 of about 1,133,444 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cloud-based Optimized Intelligent Substation Secondary System Rapid Test Model and System Design

Zhongguo dianli
A fast testing scheme for secondary system equipment based on cloud-side optimization is proposed. The cloud-side optimization capability is utilized to propose a fast testing architecture secondary system equipment and to achieve the reduction of the ...
Rongrong JI, Mengzhi WANG, Guowei ZHOU, Qingyao LIU, Hai LI, Ruofan HUANG   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Numerical and experimental study on the calcination process of the raw materials of lithium battery cathode

Case Studies in Thermal Engineering
Ternary cathode materials hold great promise in the lithium battery market, yet analyses regarding their calcination process in simulation and on-site experimentation, are few.
Zhaodong Chen, Ruifeng Dou, Hailong Peng, Ningning Liu, Mingzhao Zheng, Weili Sun, Boyang Ma, Xunliang Liu, Zhi Wen   +8 more
doaj   +1 more source

Systematic on-site testing for SARS-CoV-2 infection among asymptomatic essential workers in Montréal, Canada: a prospective observational and cost-assessment study. [PDF]

CMAJ Open, 2022
Campbell JR, Dion C, Uppal A, Yansouni CP, Menzies D.   +4 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Decentralizing genetic testing for biodiversity monitoring and biosurveillance with the Nucleic Acid Barcode Identification Tool (NABIT)

Frontiers in Conservation Science
The escalating threats to biodiversity, public health, and food security posed by emerging infectious diseases, wildlife trafficking, and invasive species expansions require novel approaches to biosurveillance.
Hal R. Holmes, Misa Winters, Cifeng Fang, Gareth Fotouhi, Maria Fernanda Baron, David L. Day, Jacqueline Mercader, David Anthony Fox, Paul M.E. Bunje, Alex Dehgan   +9 more
doaj   +1 more source

Design and Construction of Chassis Dynamometer for On-Site Testing of Tractors [PDF]

Biomechanism and Bioenergy Research
Measuring tractor performance parameters is crucial for validating manufacturer claims and selecting a suitable tractor. Field studies often face high costs and inaccuracies due to external factors and limited parameter measurement. A chassis dynamometer
Hasan Shahbazi, Aref Mardani, Arash Mohebbi, Sajjad Derafshpour   +3 more
doaj   +1 more source

Current Trends and Challenges for Rapid SMART Diagnostics at Point-of-Site Testing for Marine Toxins. [PDF]

Sensors (Basel), 2021
Dillon M, Zaczek-Moczydlowska MA, Edwards C, Turner AD, Miller PI, Moore H, McKinney A, Lawton L, Campbell K.   +8 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source