Results 11 to 20 of about 12,487 (218)

Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis.

PLoS Pathogens, 2021
Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost entirely
Germanus S Bah, Sebastian Schneckener, Steffen R Hahnel, Nicolas H Bayang, Helena Fieseler, Gabriele M Schmuck, Ralph Krebber, Anouk Sarr, Carsten Terjung, Henrietta F Ngangyung, David D Ekale, Youssouf M Mfopit, Lucien Rufener, John Graham-Brown, Vincent N Tanya, Martin Glenschek-Sieberth, Daniel Kulke, Benjamin L Makepeace   +17 more
doaj   +2 more sources

Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda—Clinical, EEG and Brain Imaging Features

Frontiers in Neurology, 2021
Globally, epilepsy is the most common chronic neurological disorder. The incidence in sub-Saharan Africa is 2-3 times higher than that in high income countries.
Rodney Ogwang, Rodney Ogwang, Rodney Ogwang, Albert Ningwa, Albert Ningwa, Pamela Akun, Pamela Akun, Paul Bangirana, Ronald Anguzu, Ronald Anguzu, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro, Richard Idro, Richard Idro   +21 more
doaj   +2 more sources

Entomological Assessment of Onchocerca Species Transmission by Black Flies in Selected Communities in the West Region of Cameroon

Pathogens, 2020
The enormity of the public health burden of onchocerciasis motivated the creation of various large-scale control programs that have depended principally on mass treatment of endemic communities with ivermectin for the elimination of the disease ...
Cabirou Mounchili Shintouo, Joel Ebai Nguve, Fru Bertha Asa, Robert Adamu Shey, Joseph Kamga, Jacob Souopgui, Stephen Mbigha Ghogomu, Rose Njemini   +7 more
doaj   +2 more sources

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

PLoS Neglected Tropical Diseases, 2020
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic shown to
Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale   +16 more
doaj   +2 more sources

A cryptic species of Onchocerca (Nematoda: Onchocercidae) in blackflies (Simulium spp.) from southern California, USA

Parasites & Vectors, 2018
Background Entomological surveillance for pathogens based on molecular screening of putative arthropod vectors such as blackflies (Diptera: Simuliidae) is becoming increasingly important.
Guilherme G Verocai, Kimberly J Nelson, R Trey Callahan, Joseph Wakoli Wekesa, Hassan K Hassan, Eric P Hoberg   +5 more
doaj   +2 more sources

Description, molecular characteristics and Wolbachia endosymbionts of Onchocerca borneensis Uni, Mat Udin & Takaoka n. sp. (Nematoda: Filarioidea) from the Bornean bearded pig Sus barbatus Müller (Cetartiodactyla: Suidae) of Sarawak, Malaysia

Parasites & Vectors, 2020
Background The genus Onchocerca Diesing, 1841 includes species of medical importance, such as O. volvulus (Leuckart, 1893), which causes river blindness in the tropics. Recently, zoonotic onchocercosis has been reported in humans worldwide.
Shigehiko Uni, Ahmad Syihan Mat Udin, Takeshi Agatsuma, Kerstin Junker, Weerachai Saijuntha, Naruemon Bunchom, Masako Fukuda, Coralie Martin, Emilie Lefoulon, Amandine Labat, Faisal Ali Anwarali Khan, Van Lun Low, Phaik Leng Cheah, Yvonne Ai-Lian Lim, Rosli Ramli, Daicus Martin Belabut, Nur Afiqah Zainuri, Makoto Matsubayashi, Hasmahzaiti Omar, Subha Bhassu, Shoji Uga, Rosli Hashim, Hiroyuki Takaoka, Mohd Sofian Azirun   +23 more
doaj   +2 more sources

Morphological and molecular characterization of Onchocerca fasciata (Nematoda, Onchocercidae) from dromedary camels (Camelus dromedarius) in Iran

Parasite, 2018
Skin nodules of Onchocerca fasciata Railliet and Henry, 1910 (Spirurida, Onchocercidae) are a common finding in dromedary camels, though with a minimal clinical impact.
Mirzaei Mohammad, Ghahvei Younes, Lefoulon Emilie, Lia Riccardo Paolo, Otranto Domenico, Martin Coralie, Sazmand Alireza   +6 more
doaj   +2 more sources

Onchocerca - infected cattle produce strong antibody responses to excretory-secretory proteins released from adult male Onchocerca ochengi worms

BMC Infectious Diseases, 2018
Background The front line molecules from filarial worms and other nematodes or helminthes are their Excretory-Secretory (ES) products. Their interaction with the host cells, proteins and immune system accounts for the skin and eye pathology or ...
Djafsia Boursou, Dieudonné Ndjonka, Albert Eisenbarth, Kingsley Manchang, Archille Paguem, Nancy Ngwafu Ngwasiri, Jacqueline Dikti Vildina, Babette Abanda, Ralf Krumkamp, Silke van Hoorn, Alfons Renz, Mbunkah Daniel Achukwi, Eva Liebau, Norbert W. Brattig   +13 more
doaj   +2 more sources

Nodding syndrome (NS) and Onchocerca Volvulus (OV) in Northern Uganda

The Pan African Medical Journal, 2017
Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth.
David Kitara Lagoro, Denis Anywar Arony
doaj   +2 more sources

Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection

PLoS Neglected Tropical Diseases, 2022
Background Onchocerciasis (“river blindness”), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium.
B. Tan, N. Opoku, S. K. Attah, K. Awadzi, A. Kuesel, J. Lazdins-Helds, C. Rayner, Victoria Ryg-Cornejo, M. Sullivan, L. Fleckenstein   +9 more
semanticscholar   +1 more source