Results 41 to 50 of about 2,783 (213)

Onchocerciasis in Ecuador: changes in prevalence of ocular lesions in Onchocerca volvulus infected individuals over the period 1980-1990

Memorias do Instituto Oswaldo Cruz, 1996
Trends in prevalence rates of onchocercal ocular lesions were examined over the period 1980 to 1990 using data from two cross-sectional surveys. There was evidence for increasing prevalence of anterior chamber microfilariae, iridocyclitis, optic atrophy,
Philip J Cooper, Roberto Proaño, Carlos Beltran, Mariela Anselmi, Ronald H Guderian   +4 more
doaj   +1 more source

Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis [PDF]

, 2016
The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in
Edwards, SW, Guimaraes, AF, Johnston, KL, Midgley, A, Pionnier, N, Tamarozzi, F, Taylor, MJ, Turner, JD   +7 more
core   +3 more sources

Evolution of Ivermectin Resistance in the Nematode Model Caenorhabditis elegans: Critical Influence of Population Size and Altered Emodepside Efficacy

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass‐drug administration control programs in humans and zoonotic hosts. Currently, experimental evidence to understand the influence of management (e.g., treatment dose and frequency) and parasite‐associated factors (e ...
Jacqueline Hellinga, Barbora Trubenova, Jessica Wagner, Marc Borchert, Jürgen Krücken, Roland R. Regoes, Hinrich Schulenburg, Georg von Samson‐Himmelstjerna   +7 more
wiley   +1 more source

The Population Biology and Transmission Dynamics of Loa loa [PDF]

, 2017
Endemic to Central Africa, loiasis – or African eye worm (caused by the filarial nematode Loa loa) – affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public ...
Basáñez, M-G, Boussinesq, M, Chesnais, C B, Pion, S D S, Walker, M, Whittaker, C   +5 more
core   +1 more source

From Aid Dependency to Self‐Reliance: Lessons From Sierra Leone and Rwanda's Strategies for Eliminating Preventable Blindness in Africa: A Perspective Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Preventable blindness remains a leading cause of disability in low‐income countries (LICs), with 91.5% of cases in Sierra Leone and 83.9% in Rwanda considered avoidable. Reliance on foreign aid has supported eye care development in Africa, yet has also fostered systemic dependency.
Babatunde Ismail Bale, Lynette Delali Amematekpor, Ebunoluwa Anne Ajibola‐Ajo, Seriki Yetunde Mutiat, Ojo Onakhe Emmanuel, Adeleke Oluwatimilehin   +5 more
wiley   +1 more source

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa

Infectious Diseases of Poverty, 2019
Background Onchocerciasis (river blindness), caused by the filarial worm species Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public health and socioeconomic concern. It is transmitted through the bite of black flies
Gebremedhin Gebrezgabiher, Zeleke Mekonnen, Delenasaw Yewhalaw, Asrat Hailu   +3 more
doaj   +1 more source

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Frauke Assmus, Ayorinde Adehin, Richard M. Hoglund, Gloria Nyaulingo, Hussein Mbarak, Said Jongo, Eveline Ackermann, Elisabeth Reus, Jennifer Keiser, Fabiana Barreira Da Silva Rocha, Sabine Specht, Ivan Scandale, Joel Tarning   +12 more
wiley   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source

Risk Factors and Genetics of Dementia in Africa

Alzheimer's &Dementia, Volume 21, Issue S6, December 2025.
Abstract Background The burden of dementia in Africa is projected to grow exponentially by the year 2050 driven by population growth, population ageing and other factors. There is an heterogenous body of knowledge on modifiable risk factors but limited understanding of the genetic architecture of dementia in Africa.
Rufus O. Akinyemi
wiley   +1 more source

NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection

Frontiers in Immunology, 2022
Lymphatic filariasis and onchocerciasis are major neglected tropical diseases affecting over 90 million people worldwide with painful and profoundly disfiguring pathologies (such as lymphoedema or blindness). Type 2 inflammation is a hallmark of filarial
Nicolas Pionnier, Nicolas Pionnier, Julio Furlong-Silva, Stefano A. P. Colombo, Amy E. Marriott, Valerine C. Chunda, Valerine C. Chunda, Bertrand L. Ndzeshang, Bertrand L. Ndzeshang, Hanna Sjoberg, John Archer, Andrew Steven, Samuel Wanji, Samuel Wanji, Mark J. Taylor, Joseph D. Turner   +15 more
doaj   +1 more source