Results 211 to 220 of about 845,274 (281)

Gastrointestinal Stromal Tumor with a Novel Mutation of KIT Proto-oncogene.

, 2001
Ryo Fukuda, Naoharu Hamamoto, Yasushi Uchida, Kohichiro Furuta, Tomoko Katsube, Hideaki Kazumori, Shunji Ishihara, Kazutoshi Amano, Kyoichi Adachi, Makoto Watanabe, Yoshikazu Kinoshita   +10 more
openalex   +2 more sources

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Extrachromosomal DNA and cancer: function, formation, and clinical implications. [PDF]

J Exp Clin Cancer Res
Wu Y, Rui R, Tian T, Zheng J, He S, Zhou L, Li X, Gong Y.   +7 more
europepmc   +1 more source

GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity

, 1991
Joseph M. Lowndes, Sunil Gupta, Shoji Osawa, Gary L. Johnson   +3 more
openalex   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao, Xinhua Feng, Aifu Lin, Lei Zhao, Stephanie Roessler, Junfang Ji   +14 more
wiley   +1 more source

The role of deubiquitinase USP33 in colorectal cancer tumorigenesis and its potential as a therapeutic target predictor. [PDF]

Discov Oncol
Dai Y, Luo X, Wu H, Luo Y, Deng Z, Wu J, Zhang L, Yan J.   +7 more
europepmc   +1 more source

Chromosomal assignment of a family of human oncogenes.

, 1983
Jeremy Ryan, P E Barker, Kohei Shimizu, Michael Wigler, F.H. Ruddle   +4 more
openalex   +1 more source

Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation [PDF]

, 2004
Culp, Lloyd A, Edsjö, Anders,, Karlsson, Jenny,, Lund University., Nilsson, Helén,, Pattyn, Filip, Påhlman, Sven,, Speleman, Frank, Vandesompele, Jo   +8 more
core   +2 more sources

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source