Results 211 to 220 of about 617,669 (345)

RFLP for TaqI of the human thyroid papillary carcinoma (PTC) oncogene [PDF]

open access: green, 1988
Paolo Radice   +8 more
openalex   +1 more source

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan   +6 more
wiley   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

open access: yesAdvanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang   +8 more
wiley   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

open access: yesAdvanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao   +13 more
wiley   +1 more source

Effective IHH gene knockout by CRISPR/Cas9 system in chicken DF-1 cells. [PDF]

open access: yesPoult Sci
Jin S   +8 more
europepmc   +1 more source

Replication of proto-oncogenes early during the S phase in mammalian cell lines

open access: green, 1987
Mohammed A. Iqbal   +3 more
openalex   +1 more source

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