Results 121 to 130 of about 369,580 (326)

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]

, 1999
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden, A Sewing, AD Catling, B Hallberg, CJ Marshall, D Woods, DK Grandy, DK Morrison, DW Rose, F Schoentgen, Ferrell, J. E. Jr, Ferrell, J. E. Jr, H Mischak, HJ Schaeffer, JT Bruder, KL Guan, M Kortenjann, OV Gjorup, RM Lavbinsky, RM Tombes, S Häfner, S Li, SA Moodie, UR Rapp, W Kolch, W Kolch   +25 more
core   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration [PDF]

, 2009
Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity.
Akiyama, Al-Ayyoubi, Askari, Bailey, Bass, Bass, Bass, Becerra, Biliran, Blacque, Brown, Cella, Coe, Dollery, Filleur, Filleur, Galis, Gao, Humphries, Huntington, Häyry, Jiang, Khalkhali-Ellis, Laura Wagstaff, Law, Li, Li, Lorna Ravenhill, Luo, McGowen, Mould, Mould, Newby, Ngamkitidechakul, Odero-Marah, Owens, Pemberton, Pemberton, Rosemary Bass, Ross, Schreiner, Schwartz, Sechler, Seftor, Sheng, Sheng, Sheng, Shi, Shi, Smith, Stephens, Vincent Ellis, Yin, Zhang, Zou   +54 more
core   +2 more sources

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

INTEGRATIVE ANALYSIS OF OMICS DATA IN ADULT GLIOMA AND OTHER TCGA CANCERS TO GUIDE PRECISION MEDICINE [PDF]

, 2017
Transcriptomic profiling and gene expression signatures have been widely applied as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer ...
hu, Xin, hu, xin
core   +1 more source

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

OncoTarget, 2012
Oncogenic fusion proteins, such as EWS-FLI1, are excellent therapeutic targets as they are only located within the tumor. However, there are currently no agents targeted toward transcription factors, which are often considered to be 'undruggable.' A ...
Julie, S., Barber-Rotenberg, Saravana, P., Selvanathan, Yali, Kong, Hayriye V. Erkizan, Tara M. Snyder, S. P. Hong, Christina L. Kobs, Natalie L. South, Stephen J. Summer, P. Monroe, M. Chruszcz, Veselin Dobrev, Perrer N. Tosso, Lauren J. Scher, W. Minor, Milton L. Brown, S. Metallo, Aykut Üren, J. Toretsky   +23 more
semanticscholar   +1 more source

Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein

EBioMedicine, 2015
ISSN:2352 ...
Sabiani, Samaneh, Geppert, Tim, Engelbrecht, Christian, Kowarz, Eric, Schneider, Gisbert, Marschalek, Rolf   +5 more
openaire   +5 more sources