Results 171 to 180 of about 103,602 (308)

ESR1 fusion proteins in breast cancer: distinguishing oncogenic drivers from passenger events. [PDF]

Oncogene
Gherghelas AM, Toseland CP.
europepmc   +1 more source

RGS proteins and G protein signalling [PDF]

The work within this thesis is concerned with the creation of a temperature-sensitive Schizosaccharomyces pombe marker protein, and the regulation of the pheromone communication system of Sz. pombe reporter strains by RGS proteins.
Pateman, Cassandra Sophie Catherine
core  

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

Durable response to selpercatinib in HOOK3-RET fusion positive, α-fetoprotein producing metastatic pancreatic ductal adenocarcinoma with intestinal-type differentiation. [PDF]

Oncol Lett
Sandhu HS, Natarajan A, Joshi S.
europepmc   +1 more source

A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions. [PDF]

J Pathol Clin Res
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Yeung MC, Saoud C, Chiang S, Hameed M, Antonescu CR.   +4 more
europepmc   +2 more sources

Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins

, 1995
The molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised.
Landgren, E,, Lavergne, C,, Anafi, M,, Cantley, L C,, Karlsson, Torbjörn,, Songyang, Z,, Welsh, Michael,, Claesson-Welsh, Lena,, Di Fiore, P P,, Pawson, T,   +9 more
core  

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Megamitochondria in alcohol-associated liver disease and cancer: a friend or foe? [PDF]

eGastroenterology
Niu M, Wei X, Ma X, Ding WX.
europepmc   +1 more source

Identification of p21 as a Direct Target of EWS-Fli1 Oncogenic Fusion Protein [PDF]

Journal of Biological Chemistry, 2003
Fumihiko Nakatani, Kazuhiro Tanaka, Riku Sakimura, Yoshihiro Matsumoto, Tomoya Matsunobu, Xu Li, Masuo Hanada, Takamitsu Okada, Yukihide Iwamoto   +8 more
openaire   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source