Results 181 to 190 of about 103,602 (308)

Mechanism of and research progress on alterations in the RET gene in thyroid cancer (Review). [PDF]

Mol Med Rep
Wei M, Wang R, Qian J, Fang Q, Tao J.
europepmc   +1 more source

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

Molecular Carcinogenesis, EarlyView.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha, Yue Liu, Gaga Geneti, Haojian Li, Xiaolin Wu, David Sun, Vaibhavi Gujar, Takashi Furusawa, Alexei Lobanov, Maggie Cam, Lipika R. Pal, Nishanth U. Nair, Chi‐Ping Day, Eytan Ruppin, Chandrayee Ghosh, Jiangnan Hu, Bhavishya Ramamoorthy, Suresh Kumar, Thorkell Andresson, King Chan, Maura O'Neill, Raj Chari, Yves Pommier, Jaydira Del Rivero, Urbain Weyemi, Electron Kebebew, Myriem Boufraqech   +26 more
wiley   +1 more source

FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy. [PDF]

Cancer Res
Gracilla DE, Menon S, Breese MR, Lin YP, Dela Cruz FS, Feinberg TY, de Stanchina E, Galic AF, Allegakoen H, Perati SR, Everin N, Vizconde T, Wen NJ, Heslin A, Somwar R, Ladanyi M, Horlbeck M, Weissman JS, Sweet-Cordero EA, Bivona TG, Tulpule A.   +20 more
europepmc   +1 more source

The Role of the eEF1A Family in Human Cancers

, 2008
Oncogene proteins are proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (oncogene proteins, fusion).
Cristiano L, GRASSI, GABRIELE, SCAGGIANTE, BRUNA, DAPAS, BARBARA   +3 more
core  

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Human Mesenchymal Stem Cell-Derived Exosomes as Engineering Vehicles of Daunorubicin for Targeted c-Mpl+ AML Therapy

International Journal of Nanomedicine
Chunmou Li,1,* Yuchen Wen,1,* Jiasheng Wang,2 Lindi Li,1 Yue He,2 Yucai Cheng,1 Junru Chen,2 Junbin Huang,1 Cheng Ouyang,1 Yong Liu,1 Ruizhi Zhou,1 Haisheng Chen,2 Fei Li,2 Qiqi Guo,2 Yun Chen,3 Chun Chen,1 Qing Zhang2 1Pediatric Hematology ...
Li C, Wen Y, Wang J, Li L, He Y, Cheng Y, Chen J, Huang J, Ouyang C, Liu Y, Zhou R, Chen H, Li F, Guo Q, Chen Y, Chen C, Zhang Q   +16 more
doaj  

Outcomes of elective discontinuation, retreatment, and alternatives to surgery in childhood fibrosarcoma. [PDF]

Transl Pediatr
Ibáñez-Navarro A, Villanueva Freije A, Aguirre-Portolés C, Pérez-Martínez A.   +3 more
europepmc   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion. [PDF]

J Hematop
Cook JR, Astbury C, Bosler DS, Molina JC, Rogers HJ, Sobecks RM, Owczarczyk AB.   +6 more
europepmc   +1 more source

Neue Ansätze des molekularen Targetings bei der Philadelphia-Chromosom-positiven Leukämie

, 2011
In Philadelphia Chromosome (Ph) positive ALL and CML the fusion between BCR and ABL leads to the BCR/ABL fusion proteins, which induces the leukemic phenotype because of the constitutive activation of multiple signaling pathways down-stream to the ...
Mian, Afsar Ali
core