Results 201 to 210 of about 103,602 (308)

CRISPR Interference to Inhibit Oncogenes for Cancer Therapy. [PDF]

Int J Mol Sci
Guo B.
europepmc   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Identification of ISZ-sTRAIL Protein as a Potent Anticancer Agent for EML4-ALK-Positive Non-Small-Cell Lung Cancer. [PDF]

Molecules
Hu J, Guo J, Qin T, Mao X, Liu Z, Ma L.
europepmc   +1 more source

The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition [PDF]

Blood Cancer Journal, 2018
Kahlon, Shira, Shreibman, Dorin, Unger, Tamar, Ben-Yehuda, Dina, Elias, Shlomo   +4 more
openaire   +2 more sources

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Liquid biopsy-based detection of acquired MET resistance enables sequential targeted therapy in MET fusion-positive NSCLC. [PDF]

Oncologist
Rosnev S, Klein K, Heukamp L, Lenk J, Joosten M, Möbs M, Grob T, Benary M, Vecchione L, Ott CE, Modest DP, Knödler M, Keller U, Frost N, Keilholz U, Kiewe P, Rieke DT.   +16 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Tissue-Specific Expression of the EWSR1::FLI1 Fusion Protein Identifies <i>col2a1a</i>-Positive Cells as a Source of Ewing Sarcoma-like Tumors in Zebrafish. [PDF]

Int J Mol Sci
Anderson RA, Chen X, Oyarbide U, Alvarez NJ, Sievers A, Schwartz GK, Corey SJ.   +6 more
europepmc   +1 more source

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Durable Response to Selpercatinib in Metastatic Colorectal Cancer Harboring a Novel <i>TIMM23B::RET</i> Fusion: A Case Report. [PDF]

Curr Oncol
Tong Z, Yang M, Weng S, Yuan Y.
europepmc   +1 more source