Results 291 to 300 of about 384,141 (378)

Cancer: From a Genetic Disorder to a Systemic Disease. [PDF]

Adv Sci (Weinh)
Wong AH, Hu Y.
europepmc   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

The expression, regulation, and function of human endogenous retroviruses in genitourinary cancers. [PDF]

Cell Death Discov
Ma W, Ji C, Abudushataer A, Liu N, Xu T, Zhao K, Qian Y, Tuerxun P, Jiang X, Xiong Z, Wang M, Jia R, Xu Z, Li Y, Ge YZ.   +14 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

From Viral Infection to Genome Reshaping: The Triggering Role of HPV Integration in Cervical Cancer. [PDF]

Int J Mol Sci
Li J, Li S.
europepmc   +1 more source

The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia

, 2013
健一 平井
openalex   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

The Differential Expression of the JAK/STAT Pathway in Breast Cancer Cells Transfected with Human Papillomavirus Oncogenes. [PDF]

Viruses
Leão SL, Parente da Silva GR, Dos Santos DL, São Marcos BF, Bezerra Fontes PH, de Oliveira Isídio BE, Simões IS, Genn Barros EF, Lussón DB, Crispim JG, Leal LRS, Silva AJD, Pereira Santos VE, de Freitas AC.   +13 more
europepmc   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Editorial: Novelties in acute myeloid leukemia: from biology to clinical applications

Frontiers in Oncology
Luca Vincenzo Cappelli, Nico Gagelmann, Hassan Awada, Carmelo Gurnari, Carmelo Gurnari   +4 more
doaj   +1 more source