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Medical Hypotheses, 2010
A given cancer is produced by a unique combination of genetic alterations that target specific genes, most often leading to activation of oncogenes and inactivation of tumor suppressor genes. Traditional oncogenes, such as RasV12, are involved in maintaining pro-survival and proliferation signals activated in the cell.
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A given cancer is produced by a unique combination of genetic alterations that target specific genes, most often leading to activation of oncogenes and inactivation of tumor suppressor genes. Traditional oncogenes, such as RasV12, are involved in maintaining pro-survival and proliferation signals activated in the cell.
openaire +2 more sources
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Nature, 1983H. Land, L. Parada, R. Weinberg
semanticscholar +1 more source
MicroRNAs as oncogenes and tumor suppressors.
New England Journal of Medicine, 2005Chang‐Zheng Chen
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RAS oncogenes: the first 30 years
Nature Reviews. Cancer, 2003Marcos Malumbres, M. Barbacid
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Addiction to Oncogenes--the Achilles Heal of Cancer
Science, 2002I. Weinstein
semanticscholar +1 more source