Results 51 to 60 of about 39,210 (216)

Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models

MedComm, Volume 7, Issue 11, November 2026.
Multiple mechanisms including senescent cell accumulation, metabolic and endotoxin‐driven stimulation of immune and endothelial cells contribute to inflammaging, the chronic low‐grade inflammatory status underlying age‐related diseases. Blocking leptin signaling in experimental models of inflammaging blunts inflammation in a model‐specific manner while
Valeria Pellegrini, Rosalba La Grotta, Alessia Metallo, Francesca Carreras, Chiara Frigé, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Francesca Rispoli, Lorenzo Drago, Cesare Celeste Berra, Raffaele Marfella, Giuseppe Paolisso, Giuseppe Matarese, Claudio Procaccini, Ilaria Spatocco, Giorgia Mele, Paola de Candia, Antonio Ceriello, Francesco Prattichizzo   +20 more
wiley   +1 more source

Factores que influyen en la toma de decisiones en oncología. Reflexión bioética acerca de la medicina centrada en el paciente

Bioethics Update
Antecedentes: Los progresos en oncología han permitido disponer de una gran cantidad de intervenciones novedosas, pero en diversas ocasiones no existe certeza sobre los resultados; al no existir una única decisión, es necesario incorporar en la toma de ...
Marytere Herrera-Martínez, Ma. Blanca Ramos-de Viesca   +1 more
doaj   +1 more source

O adolescente frente ao transplante de células tronco-hematopoiéticas: contribuições para a enfermagem oncológica [Adolescents facing hematopoietic stem cell transplantation: contributions to oncology nursing]

Revista Enfermagem UERJ, 2017
Objetivos: descrever as expectativas dos adolescentes antes de se submeterem ao transplante de células-tronco hematopoiéticas, e analisar compreensivamente suas expectativas de vida no pós- transplante.
Luana Sena Pimenta, Benedita Maria Rego Deusdará Rodrigues, Sandra Teixeira de Araújo Pacheco, Michelle Darezzo Rodrigues Nunes, Ann Mary Machado Tinoco Feitosa Rosas, Ana Claudia Moreira Monteiro   +5 more
doaj   +1 more source

Real‐world outcomes of daratumumab, bortezomib, thalidomide and dexamethasone (Dara‐VTd) induction and lenalidomide maintenance in transplant‐eligible multiple myeloma

British Journal of Haematology, EarlyView.
Edvan Q. Crusoé, Glaciano Ribeiro, João Tadeu D. Souto Filho, Jayr Schmidt Filho, Natalia Schutz, Milton A. F. Aranha, Abel Costa, Abrahao Hallack, Fernando V. Pericole, Juliana S. Lima, Breno Gusmão, Eduardo Flávio O. Ribeiro, Jorge P. Vaz, Rosane Bittencourt, Rafael Cunha, Danielle Ovigli, Luiza Berg, Ederson R. Mattos, Angelo Maiolino, Vania Hungria, on behalf of GBRAM   +20 more
wiley   +1 more source

Advancing in Sarcoma 3D Modeling: Identification of SRC as an Actionable Vulnerability in Doxorubicin‐Resistant Osteosarcoma Organoids

MedComm, Volume 7, Issue 11, November 2026.
3D organoids with long‐term growth potential can be successfully generated from sarcoma xenografts. Paired parental and doxorubicin‐resistant organoids constitute a novel 3D platform for investigating drug resistance in osteosarcoma. The authors showed that inhibition of SRC‐mediated signaling with dasatinib can reverse doxorubicin resistance in ...
Borja Gallego, Dzohara Murillo, Carmen Huergo, Daniela Corte‐Torres, Andrea Ferreras, Iván Fernández‐Vega, Adela A. Fernández‐Velasco, Verónica Rey, Enol Álvarez‐González, Alejandro Braña, Jose Luis Llorente, Mara Santarelli, Benno Schwikowski, Mónica Álvarez‐Fernández, René Rodríguez   +14 more
wiley   +1 more source

Associação entre Sertolioma e Leydigocitoma em cão não criptorquida

Pubvet
Neoplasias testiculares representam a maior casuística de tumores do sistema reprodutor, sendo seminoma, sertolioma e leydigocitoma os mais comuns. Geralmente restringem-se aos testículos e o aumento testicular é o principal sinal clínico observado ...
Sérgio Vinícius Jansen, Juliano Eble Kalif, Joelma Lucioli   +2 more
doaj   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, Volume 293, Issue 21, Page 6444-6466, November 2026.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Hemangiossarcoma hepático em cadela da raça Dobermann

Pubvet
Neste trabalho é relatado um caso de uma cadela jovem da raça Dobermann, com histórico de ingestão de palmeira cica (Cycas revoluta), nos primeiros meses de vida e apresentava alterações nas enzimas hepáticas.
Maríndia Pereira Marques, Natasha Guedes Elias , Larissa Sobolewski Magassy Baptista , Cibele Floriano Fraga   +3 more
doaj   +1 more source

Stressing factors and coping strategies used by oncology nurses Factores estresantes y estrategias de coping utilizadas por los enfermeros que actúan en oncología Fatores estressantes e estratégias de coping dos enfermeiros atuantes em oncologia

Revista Latino-Americana de Enfermagem, 2008
In the oncology specialty, many factors can result in occupational stress in nursing professionals. As an attempt to controlling this situation, individuals may use coping strategies.
Andrea Bezerra Rodrigues, Eliane Corrêa Chaves   +1 more
doaj   +1 more source

AKT Phosphorylation of FOXK2 at Ser398 Impacts Breast Cancer Cell Growth and Viability

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Higher FOXK2 protein levels are associated with increased AKT phosphorylation and chemoresistance in breast cancer cells. AKT modulates FOXK2 protein levels, with no such regulation in FOXK2 mRNA levels. GSK3β, a known substrate of AKT (dotted arrow), does not regulate FOXK2 in our cellular model.
L. T. Carneiro, J. M. R. C. Nunes, G. De Gregoriis, B. S. Mendonça, W. M. Araújo, R. C. Maia, E. W. F. Lam, R. S. Carvalho, M. A. Carvalho, A. D. Sharrocks, G. Nestal de Moraes   +10 more
wiley   +1 more source