Results 51 to 60 of about 67,680 (227)

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

EMBO Molecular Medicine, 2017
The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course.
Daniela Tosoni, Sarah Pambianco, Blanche Ekalle Soppo, Silvia Zecchini, Giovanni Bertalot, Giancarlo Pruneri, Giuseppe Viale, Pier Paolo Di Fiore, Salvatore Pece   +8 more
doaj   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, EarlyView.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

A COMPLEX CARE: COMMUNICATING BAD NEWS IN ONCOLOGY

Revista de Pesquisa Cuidado é Fundamental Online, 2012
Objetivos: Analisar as produções científicas que abordam a temática de más notícias em oncologia e discutir a comunicação das mesmas nesta área. Método: Trata-se de uma revisão bibliográfica de abordagem qualitativa.
Raquel de Abreu Pinheiro e Souza, Sônia Regina de Souza   +1 more
doaj   +1 more source

Efficacy and safety of T-DM1 in the 'common-practice' of HER2+ advanced breast cancer setting: a multicenter study [PDF]

, 2017
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (mBC).
Alesini, Daniele, Arpino, Grazia, Cannita, Katia, Carbognin, Luisa, Caruso, Michele, Cianniello, Daniela, Ciccarese, Mariangela, Cognetti, Francesco, D\u2019Ottavio, Anna Maria, De Laurentiis, Michelino, Fabbri, Agnese, Fabi, Alessandra, Filippelli, Gianfranco, Generali, Daniele, Giampaglia, Marianna, Giannarelli, Diana, La Verde, Nicla, Leonardi, Vita, Montemurro, Filippo, Moscetti, Luca, Paris, Ida, Rossello, Rosalba, Russillo, Michelangelo, Santini, Daniele, Scandurra, Giuseppa, Stani, Simonetta, Valle, Enrichetta, Zambelli, Alberto   +27 more
core   +1 more source

Immunoprofiling, sex‐ and age‐related determinants of treatment response in paediatric, adolescent and young adult Hodgkin lymphoma

British Journal of Haematology, EarlyView.
Multimodal integration of sex‐ and age‐related immune‐gene signatures with baseline tumor burden (TMTV1) improves prediction of treatment response in adolescents and young adults with classical Hodgkin lymphoma. Summary The study investigates how sex and age influence treatment response in paediatric, adolescent and young adult (AYA) classical Hodgkin ...
Valli De Re, Egesta Lopci, Giulia Brisotto, Caterina Elia, Angelo Vitullo, Veronica Paduano, Mariangela De Zorzi, Lara Mussolin, Paola Quarello, Simona Bianchi, Salvatore Buffardi, Alberto Garaventa, Paola Muggeo, Marta Pillon, Alessandra Sala, Luciana Vinti, Emanuele d'Amore, Christine Mauz‐Korholz, Maurizio Mascarin, on behalf of the AIEOP Hodgkin's Lymphoma Study Group, Alberto Garaventa, Alessandra Sala, Antonella Sau, Assunta Tornesello, Daniela Galimberti, Domenico Sperlì, Elena Facchini, Eulalia Galea, Federico Verzegnassi, Fiorina Giona, Francesca Rossi, Fulvio Porta, Irene D’Alba, Katia Perruccio, Luciana Vinti, Marco Zecca, Marta Pillon, Massimo Provenzi, Maurizio Bianchi, Maurizio Mascarin, Monica Cellini, Nadia Vacca, Paola Muggeo, Patrizia Bertolini, Piero Farruggia, Raffaella De Santis, Roberta Pericoli, Rosamaria Mura, Salvatore Buffardi, Salvatore D’Amico, Sayla Bernasconi, Simona Rinieri, Simone Cesaro, Tommaso Casini, Valerio Cecinati   +54 more
wiley   +1 more source

Hematopoietic stem cell transplantation in childhood: current status and perspectives [PDF]

, 2009
Hematopoietic stem cell transplantation is a treatment option for a large number of children with malignant and non-malignant diseases. The objective of this article is to present the current status of hematopoietic stem cell transplantation in the ...
Seber, Adriana
core   +1 more source

A humanização das salas de quimioterapia pediátricas do Rio de Janeiro : o hospital pelo olhar da criança [PDF]

, 2007
A área de investimento em Oncologia Pediátrica do Instituto Desiderata tem por missão contribuir com a melhoria das condições de tratamento e cura do câncer infanto-juvenil.Esta publicação tem por objetivo registrar o rico processo de reflexão sobre as ...
Martha Cristina Nunes Moreira, Rosa Maria de Araujo Mitre   +1 more
core  

Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer [PDF]

, 2004
The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed.
Brenna, Sylvia Michelina Fernandes, Martinez, Edson Zachaione, Pereira, Julia Santucci, Silva, Ismael Dale Cotrim Guerreiro da, Syrjänen, Kari Juhani, Zeferino, Luiz Carlos   +5 more
core   +4 more sources