Results 1 to 10 of about 191,052 (217)

Calcium-Induced Activation of a Mutant G-Protein-Coupled Receptor Causes In Vitro Transformation of NIH/3T3 Cells

Neoplasia: An International Journal for Oncology Research, 1999
The calcium-sensing receptor (CaR) is a G-proteincoupled receptor that is widely expressed, has tissuespecific functions, regulates cell growth. Activating mutations of this receptor cause autosomal dominant hypocalcemia, a syndrome characterized by ...
Ana O. Hoff, Gilbert J. Cote, Herbert A. Fritsche, Jr., Haiyan Qiu, Pamela N. Schultz, Robert F. Gagel   +5 more
doaj   +1 more source

The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2018
The ETS family of transcription factors is involved in several normal remodeling events and pathological processes including tumor progression. ETS transcription factors are divided into subfamilies based on the sequence and location of the ETS domain ...
Oorvashi Roy Puli, Brian P Danysh, Elena McBeath, Deepankar K Sinha, Nguyet M Hoang, Reid T Powell, Heather E Danysh, Maria E Cabanillas, Gilbert J Cote, Marie-Claude Hofmann   +9 more
doaj   +1 more source

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

Hematology Reports, 2018
Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas(DLBCL) with extranodal localization represent clinically and molecularly distinct entities.
Stergios Boussios, Ioannis Zerdes, Amalia Vassou, Eleni Bareta, Esmeralda Seraj, Alexandra Papoudou-Bai, Nicholas Pavlidis, Anna Batistatou, George Pentheroudakis   +8 more
doaj   +1 more source

The Inflammatory Pattern of Chronic Limb-Threatening Ischemia in Muscles: The TNF-α Hypothesis

Biomedicines, 2022
Background: Vascular inflammation plays a crucial role in peripheral arterial disease (PAD), although the role of the mediators involved has not yet been properly defined.
Diego Caicedo, Clara V. Alvarez, Sihara Perez-Romero, Jesús Devesa   +3 more
doaj   +1 more source

GFRα 1-2-3-4 co-receptors for RET Are co-expressed in Pituitary Stem Cells but Individually Retained in Some Adenopituitary Cells

Frontiers in Endocrinology, 2020
The RET tyrosine kinase receptor is expressed by the endocrine somatotroph cells of the pituitary where it has important functions regulating survival/apoptosis.
Alberto Pradilla Dieste, Miguel Chenlo, Sihara Perez-Romero, Ángela R. Garcia-Rendueles, Maria Suarez-Fariña, Montserrat Garcia-Lavandeira, Ignacio Bernabeu, José Manuel Cameselle-Teijeiro, Clara V. Alvarez   +8 more
doaj   +1 more source

The bone–muscle connection in breast cancer: implications and therapeutic strategies to preserve musculoskeletal health

Breast Cancer Research, 2022
Breast cancer and its therapies frequently result in significant musculoskeletal morbidity. Skeletal complications include bone metastases, pain, bone loss, osteoporosis, and fracture. In addition, muscle loss or weakness occurring in both the metastatic
Tarah J. Ballinger, William R. Thompson, Theresa A. Guise   +2 more
doaj   +1 more source

An aggressive and expanded phenotype in a kindred with a c.57delG SDHD mutation

Endocrinology, Diabetes & Metabolism Case Reports, 2021
Familial paraganglioma syndrome type 1 (PGL-1) is maternally imprinted, caused by SDHD mutations on the paternally inherited allele, and presents with paragangliomas and pheochromocytomas that are usually benign.
Celina Caetano, Jennifer Stroop, Faripour Forouhar, Andrea Orsey, Carl Malchoff   +4 more
doaj   +1 more source

Neuroblastoma

Revista Brasileira de Cancerologia, 2023
Em prosseguimento ao Programa de Atualização em Oncologia Pediátrica da Divisão Nacional de Câncer, foi realizado em Porto Alegre—RS, no período de 22 a 23 de abril de 1977, um Seminário de alto nível sobre Neuroblastoma, sob a coordenação local do Dr ...
Comissão Nacional de Neoplasia da Infância
doaj  

Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study

International Journal of Endocrinology, 2013
Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of ...
Hassan Shawa, Ferhat Deniz, Hadil Bazerbashi, Mike Hernandez, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra   +6 more
doaj   +1 more source

Phase 2 Study of Monotherapy with Pembrolizumab for Advanced Adrenocortical Carcinoma [PDF]

Journal of Immunotherapy and Precision Oncology
Introduction Adrenocortical carcinoma (ACC) is a rare cancer with suboptimal response to chemotherapy. The role of immunotherapy in ACC management is evolving.
Brenda Chahla, Bettzy Stephen, Juhee Song, Vania Balderrama-Brondani, Feyza Yaylaci, Matthew T. Campbell, Aung Naing, Mouhammed Amir Habra   +7 more
doaj   +1 more source