Results 11 to 20 of about 191,052 (217)

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia. [PDF]

Adv Sci (Weinh)
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Song K, Qin Y, Luo J, Liu L, Luo C, Qiu Y, Zhong Y, Zhong H, Wu K, Ni M, Wu D, Dai M, Zhu S, Chen H.   +13 more
europepmc   +2 more sources

When genetics disrupt the gut: Dysmotility and ganglioneuromatosis in multiple endocrine neoplasia type 2B syndrome [PDF]

JPGN Rep
Abstract Multiple Endocrine Neoplasia type 2B (MEN2B) is a rare hereditary cancer syndrome characterized by medullary thyroid carcinoma, mucosal neuromas, and pheochromocytoma. Gastrointestinal involvement is common and often manifests as diffuse intestinal ganglioneuromatosis (IGN), which can impair motility and lead to severe constipation, pseudo ...
Majluta Yeb A, Nasr A, Kaul A.
europepmc   +2 more sources

Multizonal anogenital neoplasia in women: a cohort analysis

BMC Cancer, 2021
Background There is currently a lack of information on full anogenital evaluation of women with a previous history of anogenital neoplasia. Methods Retrospective analysis of the Homerton Anogenital Neoplasia Service records from January 2012 to March ...
Andreia Albuquerque, Michelle A. L. Godfrey, Carmelina Cappello, Francesca Pesola, Julie Bowring, Tamzin Cuming, Anke De Masi, Adam N. Rosenthal, Peter Sasieni, Mayura Nathan   +9 more
doaj   +1 more source

The Role of TGF-β in Bone Metastases

Biomolecules, 2021
Complications associated with advanced cancer are a major clinical challenge and, if associated with bone metastases, worsen the prognosis and compromise the survival of the patients.
Trupti Trivedi, Gabriel M. Pagnotti, Theresa A. Guise, Khalid S. Mohammad   +3 more
doaj   +1 more source

Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells

Cell Death and Disease, 2023
Chimeric antigen receptor (CAR) T cell therapy is an FDA-approved treatment for several hematologic malignancies, yet not all patients respond to this treatment.
Alexandra L. Pourzia, Michael L. Olson, Stefanie R. Bailey, Angela C. Boroughs, Aditi Aryal, Jeremy Ryan, Marcela V. Maus, Anthony Letai   +7 more
doaj   +1 more source

Translational Strategies to Target Metastatic Bone Disease

Cells, 2022
Metastatic bone disease is a common and devastating complication to cancer, confounding treatments and recovery efforts and presenting a significant barrier to de-escalating the adverse outcomes associated with disease progression.
Gabriel M. Pagnotti, Trupti Trivedi, Khalid S. Mohammad   +2 more
doaj   +1 more source

3D Models as a Tool to Assess the Anti-Tumor Efficacy of Therapeutic Antibodies: Advantages and Limitations

Antibodies, 2022
Therapeutic monoclonal antibodies (mAbs) are an emerging and very active frontier in clinical oncology, with hundred molecules currently in use or being tested.
Virginia Guzzeloni, Lorenzo Veschini, Federica Pedica, Elisabetta Ferrero, Marina Ferrarini   +4 more
doaj   +1 more source

A case report of psoriasis flare following immunotherapy: Report of an important entity and literature review

SAGE Open Medical Case Reports, 2020
Immune checkpoint inhibitors, such as anti-cytotoxic T-lymphocyte–associated antigen-4 and anti-programmed death-1, are a type of cancer immunotherapy approved for late-stage malignancy treatment.
Anastasia Politi, Dimas Angelos, Davide Mauri, George Zarkavelis, George Pentheroudakis   +4 more
doaj   +1 more source

Adjuvant therapy in adrenocortical carcinoma: prognostic factors and treatment options

Endocrine Oncology, 2023
Adrenocortical carcinoma (ACC) is a rare cancer with high recurrence rates and heterogeneous clinical behavior. The role of adjuvant therapy remains unclear because of the challenges in collecting high-quality data for a rare cancer.
Ruaa Al-Ward, Celeste Zsembery, Mouhammed Amir Habra   +2 more
doaj   +1 more source

Chemotherapy Associated Ovarian Failure

Frontiers in Endocrinology, 2020
As the incidence of malignancies in young adults is increasing, fertility preservation in cancer survivors arises as a major concern. Especially among female cancer patients, pregnancy rates are estimated to be 40% lower compared to women of the same age.
Davide Mauri, Davide Mauri, Ioanna Gazouli, Georgios Zarkavelis, Alexandra Papadaki, Leonidas Mavroeidis, Stefania Gkoura, Panagiotis Ntellas, Anna-Lea Amylidi, Lampriani Tsali, Eleftherios Kampletsas   +10 more
doaj   +1 more source