Results 31 to 40 of about 191,052 (217)
Advanced Science, EarlyView.An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang +14 more
wiley +1 more source
Linfoma de Hodgkin cutáneo maligno: reporte de caso y revisión de la literatura
Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2020 El linfoma de Hodgkin (LH) es una neoplasia linfoide en la que se mezclan células malignas de Hodgkin y de Reed-Sternberg con una población heterogénea de células inflamatorias no neoplásicas como linfocitos, células plasmáticas, eosinófilos e ...
Vanessa Pérez-Carrillo +3 more
doaj +1 more source
Advanced Science, EarlyView.In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu +17 more
wiley +1 more source
Frontiers in Veterinary Science, 2023 ObjectiveTo train and validate the use of a novel artificial intelligence-based thermal imaging system as a screening tool to rule out malignancy in cutaneous and subcutaneous masses in dogs.AnimalsTraining study: 147 client-owned dogs with 233 masses ...
Gillian Dank +8 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song +11 more
wiley +1 more source
F1000Research, 2018 Inactivating mutations of the succinate dehydrogenase subunit B (SDHB) gene and the subsequent stabilization and activation of the hypoxia-inducible factor 2-alpha (HIF2α) unit are recognized hallmarks associated with the development of metastatic ...
Rodrigo Toledo, Camilo Jimenez
doaj +1 more source
Advanced Science, EarlyView.Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li +11 more
wiley +1 more source
Influence of gut microbiota on chronic lymphocytic leukemia development and aggressiveness
Gut Microbes ReportsChronic lymphocytic leukemia (CLL) is highly heterogeneous both clinically and biologically. Although genetic factors have been identified, several lines of evidence suggest a role for environmental factors in disease onset and progression.
Michela Frenquelli +11 more
doaj +1 more source
Haematologica, 2018 Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.
Andreas Agathangelidis +10 more
doaj +1 more source
Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity
Advanced Science, EarlyView.An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou +10 more
wiley +1 more source