Results 51 to 60 of about 413,503 (296)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Training and validation of a novel non-invasive imaging system for ruling out malignancy in canine subcutaneous and cutaneous masses using machine learning in 664 masses

Frontiers in Veterinary Science, 2023
ObjectiveTo train and validate the use of a novel artificial intelligence-based thermal imaging system as a screening tool to rule out malignancy in cutaneous and subcutaneous masses in dogs.AnimalsTraining study: 147 client-owned dogs with 233 masses ...
Gillian Dank, Tali Buber, Anna Rice, Noa Kraicer, Erez Hanael, Tamir Shasha, Gal Aviram, Amir Yehudayoff, Michael S. Kent   +8 more
doaj   +1 more source

World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading in fine‐needle aspiration biopsies of renal masses [PDF]

, 2018
Background Utilization of fine‐needle aspiration (FNA) biopsy for the evaluation of renal masses has been increasing at our institution. At times diagnostic material on direct smears is superior to that in the cell block/core biopsy, therefore assigning
Al Nazer, Ball, Bishop, Blute, Campbell, Dagher, Delahunt, Delahunt, Fuhrman, Gilani, Halverson, Jewett, Leone, Marconi, Millet, Moch, Pambuccian, Richard, Richard, Schmidbauer, Yang   +20 more
core   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

Population screening for colorectal cancer means getting FIT:the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT) [PDF]

, 2014
Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors?
Ahlquist, Allison, Allison, Allison, Allison, Atkin, Barrows, Brenner, Burtonwood, Callum G. Fraser, Center, Cole, Cole, Cole, Cole, Crotta, Denters, Digby, Fleisher, Fletcher, Fraser, Fraser, Fraser, Fraser, Fraser, Graeme P. Young, Grazzini, Halloran, Hardcastle, Hewitson, Hoff, Hol, Imperiale, Imperiale, James E. Allison, Jemal, Jemal, Khalid-de Bakker, Kronborg, Levi, Levi, Levin, Mandel, Morikawa, Niv, Osborn, Park, Petrelli, Potter, Potter, Potter, Potter, Potter, Qaseem, Quintero, Raginel, Robinson, Rozen, Saito, Saito, Schoen, Segnan, Segnan, Shaukat, Shimbo, Simon, Songster, Songster, St John, Steele, Steele, Stegeman, Stephen P. Halloran, Sugerman, Tao, van Roon, van Roon, van Roon, van Rossum, Vart, Vellacott, Ventura, Walsh, Williams, Young, Zajac, Zauber   +86 more
core   +3 more sources

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors [version 1; referees: 3 approved]

F1000Research, 2018
Inactivating mutations of the succinate dehydrogenase subunit B (SDHB) gene and the subsequent stabilization and activation of the hypoxia-inducible factor 2-alpha (HIF2α) unit are recognized hallmarks associated with the development of metastatic ...
Rodrigo Toledo, Camilo Jimenez
doaj   +1 more source

A systematic approach to cancer: evolution beyond selection. [PDF]

, 2017
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core   +1 more source

Functional Advantage of Central Pancreatectomy Over Distal Pancreatectomy for Benign or Low‐Grade Malignant Tumors: A Comparative Analysis Based on 75‐g Oral Glucose Tolerance Test

Annals of Gastroenterological Surgery, EarlyView.
Central pancreatectomy (CP) better preserves postoperative pancreatic endocrine function than distal pancreatectomy for benign or low‐grade malignant tumors. The 75‐g oral glucose tolerance test demonstrated that CP maintained insulin secretion and glucose tolerance, highlighting its clinical advantage as a function‐preserving procedure.
Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Yuki Okuda, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto   +9 more
wiley   +1 more source

Preterm birth after loop electrosurgical excision procedure (LEEP). how cone features and microbiota could influence the pregnancy outcome [PDF]

, 2018
OBJECTIVE: In the last years, the mean age of women who underwent cervical treatment for high-grade cervical intraepithelial neoplasia (CIN 2-3) is similar to the age of women having their first pregnancy.
Caserta, D., Catalano, A, Ciavattini, A, Colombrino, C, D'Adamo, E, Di Giuseppe, J, Frega, A, Leone, C, Mallozzi, M, Marziani, R, Pavone, M, Santomauro, M, Sesti, F   +12 more
core   +2 more sources