Results 171 to 180 of about 1,168,324 (310)
Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceNext‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner +4 morewiley +1 more sourceMedical Oncology [PDF]
, 2001 Henrik C. F. Bauer, Clement Trovik, Thor Alvegård, Pelle Gustafson, Björn Skytting, Anders Rydholm, William Kraybill, Ira J. Spiro, Jonathan Harris, David S. Ettinger, Andy Trotti, David R. Lucas, Ronald H. Blum, Burton Eisenberg +13 moreopenalex +1 more sourcePotential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk +4 morewiley +1 more sourceReport on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group [PDF]
, 2020 Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K. Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H. Beck, Anant Madabhushi, Johan Hartman, Manu Sebastian, Hugo M. Horlings, Jan Hudeček, Francesco Ciompi, David Moore, Rajendra Singh, Elvire Roblin, Marcelo Luiz Balancin, Marie‐Christine Mathieu, Jochen K. Lennerz, Pawan Kirtani, I‐Chun Chen, Jeremy Braybrooke, Giancarlo Pruneri, Sandra Demaria, Sylvia Adams, Stuart J. Schnitt, Sunil R. Lakhani, Federico Rojo, Laura Comerma, Sunil Badve, Mehrnoush Khojasteh, W. Fraser Symmans, Christos Sotiriou, Paula I. González-Ericsson, Katherine L. Pogue–Geile, Rim S. Kim, David L. Rimm, Giuseppe Viale, Stephen M. Hewitt, Thomas John, Frédérique Penault–Llorca, Shom Goel, Huang‐Chun Lien, Sibylle Loibl, Zuzana Kos, Sherene Loi, Matthew G. Hanna, Stefan Michiels, Marleen Kok, Torsten O. Nielsen, Alexander J. Lazar, Zsuzsanna Bagó-Horváth, Loes Kooreman, Jeroen van der Laak, Joel Saltz, Brandon D. Gallas, Uday Kurkure, Michael Barnes, Roberto Salgado, Lee Cooper, Aini Hyytiäinen, Akira I. Hida, Alastair M. Thompson, Alexis Lefevre, Allen M. Gown, Sadis Matalon, Anna Sapino, André L. Moreira, Andrea L. Richardson, Andrea Vingiani, Andrew M. Bellizzi, Andrew Tutt, Ángel Guerrero‐Zotano, Anita Grigoriadis, Anna Ehinger, Ana C. Garrido-Castro, Anne Vincent-Salomon, Anne‐Vibeke Lænkholm, Ashley Cimino‐Mathews, Ashok Srinivasan, Balázs Ács, Baljit Singh, Benjamin C. Calhoun, Benjamin Haibe-Kans, Benjamin Solomon, Bibhusal Thapa, Brad H. Nelson, Carlos Castaneda, Carmen Ballesteroes-Merino, Carmen Criscitiello, Carolien Boeckx, Cécile Colpaert +99 moreopenalex +1 more source
