Results 11 to 20 of about 280,925 (50)

Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy

Frontiers in Immunology, 2022
Cancer cells harbor genomic instability due to accumulated DNA damage, one of the cancer hallmarks. At least five major DNA Damage Repair (DDR) pathways are recognized to repair DNA damages during different stages of the cell cycle, comprehending base ...
Saulo Brito Silva, Carlos Wagner S. Wanderley, Leandro Machado Colli   +2 more
doaj   +1 more source

World Cancer Day 2021 - Perspectives in Pediatric and Adult Neuro-Oncology

Frontiers in Oncology, 2021
Significant advances in our understanding of the molecular genetics of pediatric and adult brain tumors and the resulting rapid expansion of clinical molecular neuropathology have led to improvements in diagnostic accuracy and identified new targets for ...
Erik P. Sulman, Erik P. Sulman, Erik P. Sulman, Erik P. Sulman, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat   +7 more
doaj   +1 more source

Validation of claims algorithms for progression to metastatic cancer in patients with breast, non-small cell lung, and colorectal cancer

Frontiers in Oncology, 2016
Background: Validated algorithms for identifying progression to metastatic cancer could permit the use of administrative claims databases for research in this area.Objective: To identify simple algorithms that could accurately detect cancer progression ...
Beth L. Nordstrom, Jason C. Simeone, Karen G. Malley, Kathy H. Fraeman, Zandra eKlippel, Mark eDurst, John H. Page, Hairong eXu   +7 more
doaj   +1 more source

Post-Marketing Surveillance of a generic Oxaliplatin (AlvoxalⓇ) in Iranian Patients with Cancer

Current Therapeutic Research, 2022
: Background: CRC is the second and third most common cancer in women and men, respectively. The national comprehensive cancer network guidelines recommend oxaliplatin-based chemotherapy as a preferred regimen for patients with advanced or metastatic ...
Farhad Shahi, Mojtaba Gorji, Assistant Professor of Pediatric Oncology, Mehrdad Payandeh, Assistant Professor of Hematology & Oncology, Hamid Rezvani, Associate Professor of Hematology & Oncology, Mohammad Vaezi, Associate Professor of Hematology & Oncology, Sharareh Seifi, Assistant Professor of Hematology & Oncology, Alireza Baari, Post doctoral fellowship, Reza Khalili-Dizaji, Post doctoral fellowship, Seyed Mehdi Hashemi, Associate Professor of Hematology & Oncology, Saeid Salimi, post doctoral fellowship, Hosein Kamranzadeh, Associate Professor of Hematology & Oncology, Babak Shazad, Post doctoral fellowship, Sina Salari, Associate Professor of Hematology & Oncology, Davoud Oulad Dameshghi, Assistant Professor of Hematology & Oncology, Mehdi Sarkheil, Post doctoral fellowship, Mehrzad Mirzania, Associate Professor of Hematology & Oncology, Nassim Anjidani, Pharm. D.   +16 more
doaj  

Promising Antineoplastic Actions of Melatonin

Frontiers in Pharmacology, 2018
Melatonin is an endogenous indoleamine with an incredible variety of properties and activities. In recent years, an increasing number of studies have investigated this indoleamine’s interaction with cancerous cells. In particular, it seems that melatonin
Gaia Favero, Enrico Moretti, Francesca Bonomini, Francesca Bonomini, Russel J. Reiter, Luigi Fabrizio Rodella, Luigi Fabrizio Rodella, Rita Rezzani, Rita Rezzani   +8 more
doaj   +1 more source

Fibrolamellar Carcinoma: A Multimodal Approach

GE: Portuguese Journal of Gastroenterology, 2020
Fibrolamellar carcinoma is a rare variant of hepatocellular carcinoma not associated with cirrhosis or viral hepatitis. Serum alpha-fetoprotein levels are usually normal; the histology is of a well-differentiated tumor, and the staging is the same as for
João Vasco Barreira, Nádia Silva, Anuraj Parmanande, Manuel Rocha, João S. Coelho, Hugo Pinto Marques, Ricardo da Luz   +6 more
doaj   +1 more source

Bispecific CD3/HER2 Targeting FynomAb Induces Redirected T Cell-Mediated Cytolysis with High Potency and Enhanced Tumor Selectivity

Antibodies, 2015
CD3 bispecific therapies retargeting T cells to tumors have recently demonstrated striking activity in patients. Several CD3 bispecific antibodies directed against various tumor targets are currently being investigated in the clinic across different ...
Ulrich Wuellner, Kristina Klupsch, Fabian Buller, Isabella Attinger-Toller, Roger Santimaria, Irene Zbinden, Patricia Henne, Dragan Grabulovski, Julian Bertschinger, Simon Brack   +9 more
doaj   +1 more source

Microsurgical reconstruction of extensive oncological scalp defects

Frontiers in Surgery, 2015
While most small to medium defects of the scalp can be covered by local flaps, large defects or complicating factors like a history of radiotherapy often require a microsurgical reconstruction.Several factors need to be considered in such procedures.
Ole eGoertz, Leon evon der Lohe, Ramón eMartínez-Olivera, Adrien eDaigeler, Kamran eHarati, Tobias eHirsch, Marcus eLehnhardt, Jonas eKolbenschlag   +7 more
doaj   +1 more source

Tumour-Associated Hypoxia: Can We Give Chimeric Antigen Receptor T Cells More Breathing Space?

European Medical Journal, 2020
Immunotherapy using chimeric antigen receptor (CAR)-engineered T cells has encountered important limitations in the transition of their use from liquid to solid tumours.
Karen I Larios Martinez, Paris Kosti, Anna Schurich, James N Arnold, John Maher   +4 more
doaj   +1 more source

Cranial internal hemipelvectomy (iliectomy) with limb sparing for a dog with ilial chondrosarcoma: A case report

Clinical Case Reports, 2022
Cranial internal hemipelvectomy can be successful for excision of ilial CSA with minimal complications. Iliectomy with adjuvant radiation therapy was well tolerated in a dog with grade II ilial CSA.
Amy C. Downey, Kyle G. Mathews, Luke Borst   +2 more
doaj   +1 more source