Results 41 to 50 of about 1,424,424 (268)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Latent Profile Analysis for Patient Activation in Patients with Essential Hypertension

Patient Preference and Adherence
Qingqing Wang,1 Xiao Xin,2 Xianhua Li1,3 1School of Nursing, Shanghai Jiao Tong University, School of Nursing, Shanghai, People’s Republic of China; 2Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Nursing, Shanghai ...
Wang Q, Xin X, Li X
doaj  

Expert Consensus on Clinical Application of Molecular Residual Disease Detection in Resectable Lung Cancer (2026 Edition)

Xiehe Yixue Zazhi
Detection of molecular residual disease (MRD) based on circulating tumor DNA holds significant application value for prognostic assessment and recurrence monitoring in resectable lung cancer.
Chinese Thoracic Oncology Group (CTONG) YOUNG
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Interleukin-6 as a Predictive Marker for Lymph Node and Distant Metastasis in Colorectal Cancer: A Retrospective Cohort Study

Cancer Management and Research
Jianjun Xiao, Muyou Tian, Guoyu Chen, Huifen Li Department of Medical Oncology, Zhongshan City People’s Hospital, Zhongshan, Guangdong, People’s Republic of ChinaCorrespondence: Huifen Li, Department of Medical Oncology, Zhongshan City People’s Hospital,
Xiao J, Tian M, Chen G, Li H
doaj  

Chemotherapy-induced adverse drug reactions in oncology patients: A prospective observational survey

Indian Journal of Medical and Paediatric Oncology, 2016
Background: Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward adverse drug reactions (ADRs).
Deepti Chopra, Harmeet S Rehan, Vibha Sharma, Ritu Mishra   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prognostic Impact of Advanced Lung Cancer Inflammation Index (ALI) on Immunotherapy Outcomes in Recurrent or Metastatic Nasopharyngeal Carcinoma: A Multicenter Post Hoc Analysis

Journal of Inflammation Research
Shihong Xu,1,* Zheran Liu,1,* Ge Song,1,* Yiyan Pei,1 Murong He,2 Junyou Ge,3 Yan Qing,3 Youneng Wei,3 Meiying Shao4 1Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of ...
Xu S, Liu Z, Song G, Pei Y, He M, Ge J, Qing Y, Wei Y, Shao M   +8 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source