Results 81 to 90 of about 7,103,570 (297)

Establishing a Geriatric Oncology Service in a Medium-Sized Swiss Hospital: Preliminary Results from the PRO-PAC Registry Study

healthbook TIMES. Oncology Hematology
# Background Older adults account for a disproportionate burden of cancer-related morbidity and mortality; however, they are often underrepresented in clinical trials and may receive suboptimal or non-individualized care.
Daniel Hasek, Elena D Chiru, Deborah Wirth, Heinz Unger, Andrea Eish, Martina Sonderegger, Marcus Vetter   +6 more
doaj   +1 more source

Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma

Scientific Reports, 2017
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development.
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento   +12 more
doaj   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Modbury Hospital Foundation brochure

Brochure for the Modbury Hospital ...
Modbury Hospital
core   +1 more source

Case Report: Trametinib in the treatment of patients with metastatic lung adenocarcinoma harboring NF1 mutation: a case series and literature review

Frontiers in Oncology
BackgroundThe neurofibromin 1 (NF1) protein regulates the downstream RAS/RAF/MEK/ERK pathway and functions as a tumor suppressor. Somatic pathogenic mutations in NF1 are found in approximately 4.7%–10% of NSCLC, with a higher frequency in lung ...
Floryane Kim, Maxime Borgeaud, Maxime Borgeaud, Claudio De Vito, Petros Tsantoulis, Petros Tsantoulis, Alfredo Addeo   +6 more
doaj   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Early experience with percutaneous photodynamic nails for sacral metastatic disease and insufficiency fractures: a retrospective cohort analysis of functionality and pain relief

BMC Musculoskeletal Disorders
Background Treatment of impending pathologic fractures and insufficiency fractures of the sacrum due to metastatic disease and radiation is challenging. The use of traditional hardware is limited by poor bone quality and presence of non-contained defects.
Marilee J. Clunk, Marcos R. Gonzalez, Sonia E. Ubong, Alisha Sodhi, Joseph O. Werenski, Hayley M. Denwood, Daniel G. Tobert, Santiago A. Lozano-Calderon   +7 more
doaj   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

A prospective study assessing patient satisfaction at a large tertiary gynecologic oncology/dysplasia unit

Patient Related Outcome Measures, 2010
Selvan Pather1, Davina Tai2, Shannon Philp1, Kathryn Nattress1, Jonathan Carter1, Christopher Dalrymple1, Ken Atkinson11The Sydney Gynaecologic Oncology Group, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia; 2Department of ...
Selvan Pather, Davina Tai, Shannon Philp, et al   +3 more
doaj