Results 81 to 90 of about 5,125,322 (307)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers? [PDF]

, 2012
The development of veterinary oncology as a speciality has benefited from the changing role of companion animals in society, and the accessibility to treatment afforded by pet insurance schemes now means that, at least in financial terms, a ...
Airley, Rachel
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A descriptive qualitative study of childhood cancer challenges in South Africa: Thematic analysis of 68 photovoice contributions

South African Journal of Oncology, 2017
Background: Many childhood cancers are treatable with cure rates between 70% and 80% in well-resourced countries, while approximately 80% of African children with cancer die without access to adequate care. South Africa has an established oncology health
Lynn B. Edwards, Linda E. Greeff
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PD-L1 expression in gastric cancer assessed with antibodies 28-8 and 22C3

Scientific Reports
Programmed cell death ligand 1 (PD-L1) has emerged as a key biomarker in determining both the progression and prognosis of gastric cancer (GC). Consequently, its detection through immunohistochemical (IHC) analysis is essential for guiding appropriate ...
Erick Andrés Cantor, Andrés Felipe Bejarano-Ramírez, Laura Chacón Zambrano, Iván Camilo Triana, Henry Alexander Vargas, Javier Mauricio Segovia, Luis Eduardo Pino, John Alejandro Murillo, Roció López   +8 more
doaj   +1 more source

Announcing a correspondence course on leadership : a project of the Virginia Cooperative Extension Service

, 1983
A brochure announcing a new correspondence course offered through the Cooperative Extension ...
Virginia Cooperative Extension Service
core  

Precision Oncology: A Global Perspective on Implementation and Policy Development [PDF]

Precision Oncology; Policy developmentOncología de precisión; Desarrollo de políticasOncologia de precisió; Desenvolupament de polítiquesDespite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full ...
AGGARWAL, CHARU, Basel-Salmon, Lina, Dienstmann, Rodrigo, Horgan, Denis, Grover, Surbhi, Thomas, David, Tanner, Marcel   +6 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Systems approach to integrative oncology in breast cancer care: service design, delivery and patient experiences from a UK center

Frontiers in Oncology
BackgroundBreast cancer affects 2.3 million women annually worldwide, with survivors experiencing substantial unmet supportive care needs around symptom management, lifestyle support, psychological wellbeing, sexual health and survivorship.
Nina Fuller-Shavel, Nina Fuller-Shavel, Lauren Watts, Nazanin Derakshan   +3 more
doaj   +1 more source