Results 61 to 70 of about 4,767 (196)

New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy

, 2018
Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells.
Lundstrom K, Kenneth Lundstrom
core   +1 more source

Targeting hematologic malignancies with oncolytic vaccinia virus constructs [PDF]

Journal for ImmunoTherapy of Cancer, 2013
Background Oncolytic viruses are a promising approach for cancer therapy. Recent clinical trials proved the safety and antitumor activity of several oncolytic viruses in solid tumors. However, very little is known about the potential of the oncolytic viruses to target hematologic malignancies. Careful analysis of the effects of the oncolytic viruses in
Chen, Nanhai, Kilinc, Mehmet, Zhang, Qian, Aguilar, Jason, Tsoneva, Desislava, Pessian, Maysam, Minev, Boris, Szalay, Aladar   +7 more
openaire   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy

Journal of Translational Medicine, 2012
Background Combination of oncolytic vaccinia virus therapy with conventional chemotherapy has shown promise for tumor therapy. However, side effects of chemotherapy including thrombocytopenia, still remain problematic.
Sturm Julia B, Hess Michael, Weibel Stephanie, Chen Nanhai G, Yu Yong A, Zhang Qian, Donat Ulrike, Reiss Cora, Gambaryan Stepan, Krohne Georg, Stritzker Jochen, Szalay Aladar A   +11 more
doaj   +1 more source

Oncolytic therapy with vaccinia virus carrying IL-24 for hepatocellular carcinoma

Virology Journal, 2022
Abstract Background Hepatocellular carcinoma (HCC) is a highly refractory cancer associated with increasing mortality, which currently lacks effective treatment options. Interleukin-24 (IL-24) is a novel tumor suppressor cytokine that can selectively induce cancer cell apoptosis, and it has been utilized as a cancer gene
Lili Deng, Xue Yang, Yuedi Ding, Jun Fan, Ying Peng, Dong Xu, Biao Huang, Zhigang Hu   +7 more
openaire   +3 more sources

Characterization of Oncolytic Vaccinia Virus Harboring the Human IFNB1 and CES2 Transgenes [PDF]

Cancer Research and Treatment, 2020
The purpose of this study was to assess characteristics of SJ-815, a novel oncolytic vaccinia virus lacking a functional thymidine kinase-encoding TK gene, and instead, having two human transgenes: the IFNB1 that encodes interferon β1, and the CES2 that encodes carboxylesterase 2, which metabolizes the prodrug, irinotecan, into cytotoxic SN-38.Viral ...
Cho, Euna, Islam, S M Bakhtiar Ul, Jiang, Fen, Park, Ju-Eun, Lee, Bora, Kim, Nam Deuk, Hwang, Tae-Ho   +6 more
openaire   +2 more sources

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

Cancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi, Toshihiro Uchihashi, Hirotaka Ito, Miwako Iwai, Yuzuri Tsurumaki Sato, Kyoko Kurioka, Sena Zeynep Usta, Minoru Tanaka, Mikihiko Kogo, Susumu Tanaka, Hiroshi Fukuhara, Tomoki Todo   +11 more
wiley   +1 more source

Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients

Journal of Translational Medicine, 2012
Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed.
Patil Sandeep S, Gentschev Ivaylo, Nolte Ingo, Ogilvie Gregory, Szalay Aladar A   +4 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Immune mediated and direct killing of colorectal cancer by reovirus [PDF]

, 2012
Colorectal cancer remains the second most prevalent cancer in the world. Novel treatment strategies are necessary, especially for the treatment of metastatic disease.
Adair, Robert Allan
core