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Oncolytic viruses for cancer immunotherapy [PDF]
Journal of Hematology & Oncology, 2020 In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, and how they can be used to complement other ...
Otto Hemminki +2 more
doaj +8 more sources
Tumor Tropism of DNA Viruses for Oncolytic Virotherapy [PDF]
Viruses, 2023 Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA genome.
Junior A. Enow +2 more
doaj +3 more sources
Clinical Application of Oncolytic Viruses: A Systematic Review [PDF]
International Journal of Molecular Sciences, 2020 Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons.
Aman Chauhan, Chauhan Aman
exaly +4 more sources
Viruses, 2021 Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became an indispensable tool for the treatment of many malignant tumors.
Alexander Malogolovkin +5 more
doaj +2 more sources
Clinical Trials of Oncolytic Viruses in Breast Cancer
Frontiers in Oncology, 2021 Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic ...
Mary E. Carter +3 more
doaj +2 more sources
Oncolytic Viruses for Malignant Glioma: On the Verge of Success?
Viruses, 2021 Glioblastoma is one of the most difficult tumor types to treat with conventional therapy options like tumor debulking and chemo- and radiotherapy.
Yogesh R. Suryawanshi, Autumn J. Schulze
doaj +3 more sources
Oncolytic viruses: a new class of immunotherapy drugs
Nature Reviews Drug Discovery, 2015 Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour responses through a dual mechanism of action that is dependent on selective tumour cell killing and the induction of systemic anti-tumour immunity.
Andrew Zloza +2 more
exaly +2 more sources
Combination of oncolytic viruses and immune checkpoint inhibitors for treatment of high-grade gliomas [PDF]
Frontiers in NeurologyHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Zhihong Qian +4 more
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Oncolytic viruses as cancer therapeutics: From mechanistic insights to clinical translation. [PDF]
Mol TherOncolytic virotherapy is a therapeutic approach that leverages genetically engineered or naturally occurring viruses to selectively target and destroy cancer cells while sparing normal tissues. This review provides an overview of the mechanisms of action
Alwithenani A, Hengswat P, Chiocca EA.
europepmc +2 more sources
Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
doaj +2 more sources