Results 1 to 10 of about 19,732 (239)
Oncolytic viruses for cancer immunotherapy [PDF]
Journal of Hematology & Oncology, 2020 In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, and how they can be used to complement other ...
Otto Hemminki +2 more
doaj +6 more sources
Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame. [PDF]
PLoS ONE, 2012 Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway.
Marijke van Rikxoort +7 more
doaj +2 more sources
CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses
Viruses, 2016 The development of oncolytic viruses has led to an emerging new class of cancer therapeutics. Although the safety profile has been encouraging, the transition of oncolytic viruses to the clinical setting has been a slow process due to modifications ...
Ming Yuan +3 more
doaj +2 more sources
Combination of oncolytic viruses and immune checkpoint inhibitors for treatment of high-grade gliomas. [PDF]
Front NeurolHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Qian Z, Gao Q, Zhang W.
europepmc +2 more sources
Fusogenic Viruses in Oncolytic Immunotherapy [PDF]
Cancers, 2018 Oncolytic viruses are under intense development and have earned their place among the novel class of cancer immunotherapeutics that are changing the face of cancer therapy.
Jennifer Altomonte, Teresa Krabbe
core +3 more sources
Biologics: Targets & Therapy, 2018 Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells.
Lundstrom K
doaj +3 more sources
Oncolytic viruses as anticancer vaccines [PDF]
Frontiers in Oncology, 2014 Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well. Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses are now designed as ...
Cristina-Ileana Ureche +9 more
core +4 more sources
Oncolytic viruses and pancreatic cancer
Cancer Treatment and Research Communications, 2022 Background: Today, the pancreatic cancer prognosis is poor and genetic technology is developing to treat various types of cancers. Scientists are actively looking for a new technique to design a therapeutic strategy to treat pancreatic cancer.
Hamidi-Sofiani, V. +5 more
core +4 more sources
Tumor Tropism of DNA Viruses for Oncolytic Virotherapy
Viruses, 2023 Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA genome.
Junior A. Enow +2 more
doaj +2 more sources
Recent Clinical Experience With Oncolytic Viruses.
Current Pharmaceutical Biotechnology, 2020 There has been interest in using viruses to treat cancer for over a century. Recent clinical efforts, driven on by significant preclinical advances, have focussed on the safety of using replication-competent viruses. Recently published clinical trials of
Prestwich, R +6 more
core +5 more sources