Results 11 to 20 of about 284,324 (192)
Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame. [PDF]
PLoS ONE, 2012 Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway.
Marijke van Rikxoort +7 more
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Oncolytic viruses for cancer immunotherapy [PDF]
Journal of Hematology & Oncology, 2020 In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, and how they can be used to complement other ...
Otto Hemminki +2 more
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CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses
Viruses, 2016 The development of oncolytic viruses has led to an emerging new class of cancer therapeutics. Although the safety profile has been encouraging, the transition of oncolytic viruses to the clinical setting has been a slow process due to modifications ...
Ming Yuan +3 more
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New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy [PDF]
Biologics: Targets & Therapy, 2018 Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells.
Lundstrom K
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Development of a WNT-selective oncolytic adenovirus for imaging the therapy of colorectal cancers. [PDF]
, 2008 PhDIntroduction: The concept of oncolytic adenoviruses has been validated in preclinical studies but clinical trials have demonstrated that the virus spread remains limited and the virus fails to infect all cancer cells in a tumour.
Peerlinck, Inge D. L.
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Assessment and development of adenovirus type 11 for cancer therapy [PDF]
, 2010 PhDThe efficacy of oncolytic virotherapy is influenced by the interactions between the tumour, virus and host immunity. The first generation of oncolytic adenoviruses, based on serotype 5 (Ad5), has achieved limited success in clinical trials.
Wong, Han Hsi
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Oncolytic Virus Immunotherapy [PDF]
, 2022 Dear Readers, Oncolytic Viruses (OV) are self-propagating agents that can selectively induce the lysis of cancer cells while sparing normal tissues. OV-mediated cancer cell death is often immunogenic and triggers robust anticancer immune responses and ...
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Molecular Therapy: Oncolytics, 2019 Measles virus (MeV) is naturally cytolytic by extensive cell-to-cell fusion. Vaccine-derived MeV is toxic for cancer cells and is clinically tested as oncolytic virus.
Jan R.H. Hanauer +3 more
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Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?
Molecular Therapy: Oncolytics, 2022 Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer ...
Victor A. Naumenko +4 more
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Global Challenges, 2023 Oncolytic viruses have found a good place in the treatment of cancer. Administering oncolytic viruses directly or by applying genetic changes can be effective in cancer treatment through the lysis of tumor cells and, in some cases, by inducing immune ...
Hai Zou, Xiao‐Zhou Mou, Biao Zhu
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