Results 21 to 30 of about 284,324 (192)
The gamble between oncolytic virus therapy and IFN
Frontiers in Immunology, 2022 Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects.
Qingbo Li +10 more
doaj +1 more source
Pharmaceutics, 2022 Oncolytic virotherapy is a type of nanomedicine with a dual antitumor mechanism. Viruses are engineered to selectively infect and lyse cancer cells directly, leading to the release of soluble antigens which induce systemic antitumor immunity ...
Qing Ji +4 more
doaj +1 more source
Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
core +4 more sources
Viruses, 2021 Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became an indispensable tool for the treatment of many malignant tumors.
Alexander Malogolovkin +5 more
doaj +1 more source
Tumor Tropism of DNA Viruses for Oncolytic Virotherapy
Viruses, 2023 Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA genome.
Junior A. Enow +2 more
doaj +1 more source
Recent advances in oncolytic virus therapy for hepatocellular carcinoma
Frontiers in Oncology, 2023 Hepatocellular carcinoma (HCC) is a highly refractory cancer and the fourth leading cause of cancer-related mortality worldwide. Despite the development of a detailed treatment strategy for HCC, the survival rate remains unsatisfactory.
Licheng Zhu +14 more
doaj +1 more source
The role of autophagy in neoplastic cell response to oncolytic viruses [PDF]
, 2009 Oncolytic conditionally replicating adenoviruses (CRAds) are viral mutants able to selectively replicate in tumour cells. CRAds are considered a promising platform for cancer therapy. dl922-947, bearing a mutation in E1A gene and AdΔΔ, carrying mutations
Botta, Ginevra
core +1 more source
Oncolytic Viruses for Malignant Glioma: On the Verge of Success?
Viruses, 2021 Glioblastoma is one of the most difficult tumor types to treat with conventional therapy options like tumor debulking and chemo- and radiotherapy.
Yogesh R. Suryawanshi, Autumn J. Schulze
doaj +1 more source
Comprehensive assessment on the applications of oncolytic viruses for cancer immunotherapy
Frontiers in Pharmacology, 2022 The worldwide burden of cancers is increasing at a very high rate, including the aggressive and resistant forms of cancers. Certain levels of breakthrough have been achieved with the conventional treatment methods being used to treat different forms of ...
Richard Kolade Omole +14 more
doaj +1 more source
Oncolytic Virotherapy: From Bench to Bedside
Frontiers in Cell and Developmental Biology, 2021 Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years.
Ludi Yang +9 more
doaj +1 more source