Results 41 to 50 of about 284,324 (192)
MedComm – Oncology, 2023 The most deadly and aggressive form of brain cancer is called a glioblastoma multiforme. Following diagnosis, the median duration of survival is only 14 months.
Tanvir Ahmed
doaj +1 more source
Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Advanced Science, EarlyView.Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao +2 more
wiley +1 more source
Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics
Frontiers in Molecular Biosciences, 2022 Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators.
Virginia Corbett +3 more
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Advanced Science, EarlyView.Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang +11 more
wiley +1 more source
Advanced Science, EarlyView.Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang +14 more
wiley +1 more source
Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma
Advanced NanoBiomed Research, EarlyView.Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira +7 more
wiley +1 more source
Oncolytic adenovirus dl922-947 targets the DNA damage signaling pathway and enhances the effects of radiation therapy [PDF]
, 2011 Replication selective oncolytic viruses (OVs) are a rapidly expanding therapeutic platform for cancer treatment. OVs are characterized by genetic alterations that ablate critical viral protein functions essential for viral replication in normal cells ...
Abagnale, Antonella
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Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors
Viruses, 2015 Oncolytic viruses represent a diverse class of replication competent viruses that curtail tumor growth. These viruses, through their natural ability or through genetic modifications, can selectively replicate within tumor cells and induce cell death ...
Karishma R. Rajani, Richard G. Vile
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Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor
Biotechnology and Bioengineering, EarlyView.ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe +5 more
wiley +1 more source