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Comprehensive assessment on the applications of oncolytic viruses for cancer immunotherapy
Frontiers in Pharmacology, 2022 The worldwide burden of cancers is increasing at a very high rate, including the aggressive and resistant forms of cancers. Certain levels of breakthrough have been achieved with the conventional treatment methods being used to treat different forms of ...
Richard Kolade Omole +14 more
doaj +1 more source
Oncolytic Virotherapy: From Bench to Bedside
Frontiers in Cell and Developmental Biology, 2021 Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years.
Ludi Yang +9 more
doaj +1 more source
Oncolytic viruses as a promising therapeutic strategy for hematological malignancies.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 The incidence of hematological malignancies such as multiple myeloma, leukemia, and lymphoma has increased over time. Although bone marrow transplantation, immunotherapy and chemotherapy have led to significant improvements in efficacy, poor prognosis in
Chen Yang +6 more
semanticscholar +1 more source
The current status of oncolytic viral therapy for head and neck cancer
World Journal of Otorhinolaryngology-Head and Neck Surgery, 2016 Objective: Cancer affects the head and neck region frequently and leads to significant morbidity and mortality. Oncolytic viral therapy has the potential to make a big impact in cancers that affect the head and neck. We intend to review the current state
Matthew O. Old +4 more
doaj +1 more source
Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy?
Journal for ImmunoTherapy of CancerCytokines are small proteins that regulate the growth and functional activity of immune cells, and several have been approved for cancer therapy. Oncolytic viruses are agents that mediate antitumor activity by directly killing tumor cells and inducing ...
Hongbin Wang +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 The recent successes of tumor immunotherapy approaches, such as immune checkpoint blockade (ICB) and chimeric antigen receptor T cell (CAR-T) therapy, have revolutionized cancer treatment, improving efficacy and extending treatment to a larger proportion
T. Shi +4 more
semanticscholar +1 more source
Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles [PDF]
, 2015 Immunostimulatory gene therapy has been developed during the past twenty years. The aim of immunostimulatory gene therapy is to tilt the suppressive tumor microenvironment to promote anti-tumor immunity.
Loskog, Angelica, Angelica Loskog
core +1 more source
Journal of Translational Medicine, 2012 Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed.
Patil Sandeep S +4 more
doaj +1 more source
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
Advances in preclinical and clinical studies of oncolytic virus combination therapy
Frontiers in OncologyOncolytic viruses represent a distinct class of viruses that selectively infect and destroy tumor cells while sparing normal cells. Despite their potential, oncolytic viruses encounter several challenges as standalone therapies.
Wenlong Du +4 more
doaj +1 more source