Results 71 to 80 of about 1,862,769 (263)
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
The role of autophagy in neoplastic cell response to oncolytic viruses [PDF]
, 2009 Oncolytic conditionally replicating adenoviruses (CRAds) are viral mutants able to selectively replicate in tumour cells. CRAds are considered a promising platform for cancer therapy. dl922-947, bearing a mutation in E1A gene and AdΔΔ, carrying mutations
Botta, Ginevra
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Harnessing the power of oncolytic viruses for advancing cancer therapy
Cancer Treatment and Research CommunicationsOncolytic viruses are a novel and promising approach to cancer treatment. These viruses are either naturally occurring or genetically engineered to target and kill cancer cells while sparing healthy tissue.
Yismaw Alemie Alemayehu +1 more
doaj +1 more source
Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics
Frontiers in Molecular Biosciences, 2022 Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators.
Virginia Corbett +3 more
doaj +1 more source
CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors
Advanced Science, EarlyView.Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen +12 more
wiley +1 more source
Development of a WNT-selective oncolytic adenovirus for imaging the therapy of colorectal cancers. [PDF]
, 2008 PhDIntroduction: The concept of oncolytic adenoviruses has been validated in preclinical studies but clinical trials have demonstrated that the virus spread remains limited and the virus fails to infect all cancer cells in a tumour.
Peerlinck, Inge D L +1 more
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Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]
, 2010 The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Enrico N. De Toni +32 more
core +1 more source
Advanced Science, EarlyView.Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang +11 more
wiley +1 more source
Regulation of adenovirus replication by miR-199 confers a selective oncolytic activity in hepatocellular carcinoma [PDF]
, 2012 Oncolytic virotherapy represents a growing field of experimental cancer therapy. For safe and effective virotherapy, restricted tissue expression and replication of the virus is desirable.
Khalid Elamin Elhag, Baha Eldin
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MedComm – Oncology, 2023 The most deadly and aggressive form of brain cancer is called a glioblastoma multiforme. Following diagnosis, the median duration of survival is only 14 months.
Tanvir Ahmed
doaj +1 more source