Results 91 to 100 of about 1,862,769 (263)
Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances
Molecular Therapy: Oncolytics, 2019 Oncolytic viruses (OVs) are powerful new therapeutic agents in cancer therapy. With the first OV (talimogene laherparepvec [T-vec]) obtaining US Food and Drug Administration approval, interest in OVs has been boosted greatly.
Meijun Zheng +3 more
semanticscholar +1 more source
Detecting communities when order and direction matter in social network analysis
Canadian Journal of Statistics, EarlyView.Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley +1 more source
Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology
Exploration, EarlyView.Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen +8 more
wiley +1 more source
Characterization of Oncolytic Herpesviruses [PDF]
, 2008 Oncolytic viruses are able to selectively replicate in tumour cells and are an attractive new avenue of cancer therapy that lacks the toxic side effects of current treatment modalities. HSV-1 mutants lacking ICPO are promising oncolytic vectors, however,
Rodrigues, Rebecca
core
The multifunctional NS1 protein of influenza A viruses [PDF]
, 2012 The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection.
Hale, Benjamin Geoffrey +3 more
core +1 more source
The combination therapy of oncolytic virotherapy
Frontiers in PharmacologyIntroduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killing efficiency, excellent targeting capabilities, minimal adverse reactions, and multiple pathways for tumor destruction.
Yue Wang +6 more
doaj +1 more source
Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials
International Journal of Molecular Sciences, 2020 Immuno-oncology (IO) has been an active area of oncology research. Following US FDA approval of the first immune checkpoint inhibitor (ICI), ipilimumab (human IgG1 k anti-CTLA-4 monoclonal antibody), in 2011, and of the first oncolytic virus, Imlygic ...
June Kyu Hwang, Jinwoo Hong, C. Yun
semanticscholar +1 more source
Advances in Immunological Combination Therapy for Colorectal Cancer
iMetaMed, EarlyView.Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source
Arming vaccinia virus for pancreatic cancer oncolytic virotherapy [PDF]
, 2011 PhDVaccinia virus is a 250-300nm enveloped DNA virus from the poxvirus family and is used as a vector for oncolytic viral gene therapy. No unique cell surface receptor has been identified for Vaccinia virus and the reasons for its tropism for cancer ...
Hiley, Crispin
core
Retargeting strategies for oncolytic herpes simplex viruses [PDF]
, 2016 Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy ...
Costanza Casiraghi +13 more
core +1 more source