Results 91 to 100 of about 284,324 (192)
Advanced Science, Volume 13, Issue 51, 14 September 2026.Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang +11 more
wiley +1 more source
Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles
, 2015 Immunostimulatory gene therapy has been developed during the past twenty years. The aim of immunostimulatory gene therapy is to tilt the suppressive tumor microenvironment to promote anti-tumor immunity.
Loskog, Angelica, Angelica Loskog
core +1 more source
Retargeting strategies for oncolytic herpes simplex viruses [PDF]
, 2016 Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy ...
Costanza Casiraghi +13 more
core +1 more source
Spatial Omics in High‐Grade Gliomas: Mapping Immune–Tumor Niches for Precision Therapy
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT High‐grade gliomas (HGGs), particularly glioblastoma (GBM), remain among the most lethal human cancers despite decades of molecular profiling and therapeutic innovation. A primary reason for treatment failure is that HGG biology is spatial: malignant cell states, immune suppression, metabolic stress, and therapeutic resistance are organized ...
Saniyah Shaikh +8 more
wiley +1 more source
Detecting communities when order and direction matter in social network analysis
Canadian Journal of Statistics, Volume 54, Issue 3, September 2026.Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley +1 more source
Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]
, 2013 MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core
Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley +1 more source
Oncolytic vaccinia virus and cancer immunotherapy
Frontiers in ImmunologyOncolytic virotherapy (OVT) is a promising form of cancer treatment that uses genetically engineered viruses to replicate within cancer cells and trigger anti-tumor immune response.
Lihua Xu +5 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.This review integrates ICC‐specific and broader BTC evidence to define how desmoplastic stroma, immune‐cell crosstalk, metabolic remodelling, and molecular heterogeneity shape immunotherapy response and resistance. It highlights biomarker‐guided, mechanism‐based combinations while emphasizing the limited maturity of ICC‐specific evidence for emerging ...
Mengyao Chen +5 more
wiley +1 more source
Advances in Oncolytic Viral Therapy in Melanoma: A Comprehensive Review
VaccinesCheckpoint inhibitor therapy revolutionized the treatment of patients with melanoma. However, in patients where melanoma exhibits resistance to checkpoint inhibitor therapy, the treatment options are limited.
Ayushi Garg +12 more
doaj +1 more source